Skip to main content

Table 3 Key studies evaluating dietary therapies head to head

From: Diet and irritable bowel syndrome: an update from a UK consensus meeting

Lead author Year Study design Study duration Total number of participants Comparator diets Outcome
Bohn [48] 2015 RCT 4 weeks 75 IBS patients (Rome III) TDA and LFD No difference in clinical responders between TDA and LFD (50% vs 46%, p = 0.72)
Eswaran [49] 2016 RCT 4 weeks 92 IBS-D patients (Rome III) mNICE and LFD No difference in adequate symptom relief between mNICE and LFD (41% vs 52%, p = 0.31)
Zahedi [50] 2017 RCT 6 weeks 110 IBS-D patients (Rome III) General dietary advice and LFD LFD significantly improved overall gastrointestinal symptom scores, stool frequency and consistency compared to generalised dietary advice (p < 0.001, p < 0.001 and p = 0.003, respectively)
Paduano [23] 2019 Prospective study 4 weeks 42 IBS patients (Rome IV) LFD, GFD and Mediterranean diet LFD, GFD and Mediterranean diet showed the same efficacy in reducing disease severity (p < 0.01)
Goyal [52] 2021 RCT 16 weeks 101 IBS-D patients (Rome IV) TDA and LFD Higher proportion of responders on LFD compared to TDA at both week 4 (63% vs 41%, p = 0.0448) and week 16 (53% vs 31%, p = 0.0274)
Rej [20] 2022 RCT 4 weeks 101 IBS patients (Rome IV) TDA, LFD and GFD No difference in clinical response between TDA, LFD and GFD (42% vs 55% vs 58%, p = 0.43)
  1. Total number of studies; n = 6, total number of participants; n = 521