Low CRP (≤ 3mg/L) | High CRP (>3 mg/L) | FDR-adjusted Pheterogeneity | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
No (incident cases) | Person years | HR (95%CI) | P | No (incident cases) | Person years | HR (95%CI) | P | |||
Overall cancer | 327,031 (26,173) | 2,237,479 | 1.04 (1.03,1.06) | <0.001 | <0.001 | 93,933 (8,806) | 635,846 | 1.01 (1.01,1.01) | <0.001 | <0.001 |
Head & neck (C00–14) | 301,209 (351) | 2,137,461 | 1.08 (0.93,1.25) | 0.318 | 0.663 | 85,283 (156) | 603,797 | 1.02 (0.99,1.05) | 0.180 | 0.482 |
Esophagus (C15) | 301,201 (344) | 2,137,476 | 1.14 (0.99,1.32) | 0.078 | 0.434 | 85,273 (146) | 603,701 | 1.04 (1.01,1.07) | 0.014 | 0.217 |
Stomach (C16) | 301,087 (229) | 2,136,975 | 1.05 (0.87,1.26) | 0.614 | 0.873 | 85,232 (106) | 603,559 | 1.03 (0.99,1.07) | 0.154 | 0.833 |
Colorectal (C18–20) | 303,003 (2,145) | 2,144,527 | 1.11 (1.04,1.18) | 0.001 | 0.033 | 85,917 (791) | 605,899 | 1.02 (1.00,1.03) | 0.027 | 0.006 |
Liver (C22) | 301,037 (179) | 2,136,852 | 1.20 (0.98,1.47) | 0.080 | 0.235 | 85,230 (103) | 603,594 | 1.01 (0.97,1.05) | 0.788 | 0.096 |
Gallbladder (C23–24) | 300,952 (94) | 2,136,473 | 0.87 (0.65,1.17) | 0.351 | 0.873 | 85,172 (45) | 603,354 | 0.90 (0.82,0.99) | 0.035 | 0.808 |
Pancreas (C25) | 301,268 (410) | 2,137,813 | 1.14 (0.99,1.30) | 0.066 | 0.163 | 85,286 (159) | 603,798 | 0.99 (0.95,1.02) | 0.510 | 0.052 |
Lung (C33–34) | 301,995 (1,137) | 2,140,855 | 1.26 (1.16,1.36) | <0.001 | <0.001 | 85,882 (755) | 606,121 | 1.03 (1.02,1.05) | <0.001 | <0.001 |
Melanoma (C43) | 301,966 (1,111) | 2,140,358 | 0.98 (0.9,1.07) | 0.655 | 0.663 | 85,437 (310) | 604,460 | 1.01 (0.99,1.04) | 0.238 | 0.464 |
Non-melanotic skin (C44) | 309,450 (8,597) | 2,170,575 | 1.01 (0.97,1.04) | 0.729 | 0.945 | 87,430 (2,305) | 612,401 | 1.01 (1.00,1.02) | 0.128 | 0.945 |
Breast (C50) | 160,803 (3,644) | 1,130,896 | 1.07 (1.02,1.13) | 0.003 | 0.007 | 51,446 (1,371) | 361,233 | 0.99 (0.98,1.00) | 0.137 | 0.001 |
Uterus (C54-55) | 157,651 (491) | 1,119,136 | 1.13 (1.00,1.28) | 0.050 | 0.226 | 50,382 (306) | 357,326 | 1.01 (0.99,1.04) | 0.321 | 0.082 |
Ovary (C56) | 157,548 (388) | 1,118,715 | 1.12 (0.97,1.29) | 0.126 | 0.304 | 50,223 (147) | 356,717 | 1.00 (0.96,1.04) | 0.993 | 0.138 |
Prostate (C61) | 148,034 (4,337) | 1,035,523 | 0.99 (0.95,1.03) | 0.649 | 0.824 | 36,092 (1,043) | 250,894 | 1.00 (0.99,1.01) | 0.811 | 0.712 |
Kidney (C64) | 301,320 (463) | 2,137,990 | 1.13 (0.99,1.28) | 0.066 | 0.477 | 85,362 (235) | 604,047 | 1.05 (1.03,1.07) | <0.001 | 0.278 |
Bladder (C67) | 301,270 (412) | 2,137,591 | 1.05 (0.91,1.20) | 0.524 | 0.819 | 85,281 (154) | 603,785 | 1.01 (0.98,1.05) | 0.394 | 0.670 |
CNS (C70–72) | 301,185 (327) | 2,137,370 | 1.14 (0.98,1.33) | 0.092 | 0.154 | 85,232 (105) | 603,587 | 0.96 (0.92,1.01) | 0.113 | 0.037 |
Thyroid (C73) | 301,031 (173) | 2,136,726 | 1.07 (0.86,1.32) | 0.553 | 0.819 | 85,179 (52) | 603,385 | 1.01 (0.96,1.07) | 0.617 | 0.656 |
Non-Hodgkin lymphoma (C82–85, 96) | 301,634 (776) | 2,139,208 | 1.08 (0.98,1.20) | 0.123 | 0.477 | 85,447 (320) | 604,276 | 1.02 (1.00,1.05) | 0.040 | 0.282 |
Multiple myeloma (C90) | 301,172 (315) | 2,137,379 | 0.89 (0.76,1.05) | 0.182 | 0.625 | 85,211 (84) | 603,538 | 0.96 (0.91,1.02) | 0.178 | 0.398 |
CLL (C91) | 301,166 (308) | 2,137,248 | 0.83 (0.70,0.98) | 0.033 | 0.154 | 85,205 (78) | 603,491 | 1.00 (0.95,1.05) | 0.924 | 0.042 |