Table 3 Hazard ratios (HRs) for cancer outcomes among three CRP groups based on observation data (compared with low CRP (≤1 mg/L) group, the hazard ratio for cancer risk among average/high CRP groups (per 1 mg/L higher CRP concentration))

Overall cancer

166,888 (12,380)

160,143 (13,793)

1.05 (1.02, 1.07)

0.001

<0.001

93,933 (8806)

1.15 (1.12, 1.18)

<0.001

<0.001

Head & neck (C00–14)

154,674 (166)

146,535 (185)

1.06 (0.85, 1.31)

0.617

0.006

85,283 (156)

1.46 (1.15, 1.85)

0.002

0.002

Esophagus (C15)

154,643 (136)

146,558 (208)

1.20 (0.96, 1.49)

0.115

0.064

85,273 (146)

1.31 (1.01, 1.68)

0.038

0.038

Stomach (C16)

154,605 (97)

146,482 (132)

1.10 (0.84, 1.44)

0.500

0.064

85,232 (106)

1.38 (1.02, 1.87)

0.034

0.035

Colorectal (C18–20)

155,467 (959)

147,536 (1186)

1.11 (1.02, 1.21)

0.019

<0.001

85,917 (791)

1.27 (1.14, 1.40)

<0.001

<0.001

Liver (C22)

154,584 (76)

146,453 (103)

1.10 (0.81, 1.50)

0.523

0.003

85,230 (103)

1.73 (1.25, 2.40)

0.001

0.001

Gallbladder (C23–24)

154,553 (45)

146,399 (49)

0.82 (0.54, 1.24)

0.344

0.818

85,172 (45)

1.06 (0.67, 1.68)

0.805

0.818

Pancreas (C25)

154,678 (170)

146,590 (240)

1.15 (0.94, 1.41)

0.164

0.212

85,286 (159)

1.18 (0.93, 1.50)

0.162

0.154

Lung (C33–34)

154,927 (419)

147,068 (718)

1.37 (1.21, 1.55)

<0.001

<0.001

85,882 (755)

2.08 (1.83, 2.36)

<0.001

<0.001

Melanoma (C43)

155,064 (559)

146,902 (552)

1.01 (0.89,1.14)

0.936

0.792

85,437 (310)

1.03 (0.89, 1.21)

0.661

0.684

Non-melanotic skin (C44)

158,800 (4294)

150,650 (4,303)

0.99 (0.95,1.04)

0.743

0.818

87,430 (2305)

0.99 (0.94, 1.05)

0.814

0.785

Breast (C50)

83,335 (1704)

77,468 (1940)

1.15 (1.08, 1.23)

<0.001

<0.001

51,446 (1371)

1.20 (1.11, 1.31)

<0.001

<0.001

Uterus (C54–55)

81,841 (210)

75,810 (281)

1.01 (0.84, 1.21)

0.957

0.116

50,382 (306)

1.20 (0.97, 1.47)

0.087

0.074

Ovary (C56)

81,804 (173)

75,744 (215)

1.27 (1.03, 1.56)

0.028

0.024

50,223 (147)

1.37 (1.07, 1.76)

0.014

0.011

Prostate (C61)

74,992 (2116)

73,042 (2221)

0.99 (0.93, 1.06)

0.832

0.221

36,092 (1043)

0.94 (0.87, 1.02)

0.134

0.171

Kidney (C64)

154,689 (181)

146,631 (282)

1.26 (1.04, 1.53)

0.018

<0.001

85,362 (235)

1.64 (1.33, 2.03)

<0.001

<0.001

Bladder (C67)

154,689 (181)

146,581 (231)

1.01 (0.83, 1.23)

0.929

0.562

85,281 (154)

1.09 (0.87, 1.38)

0.447

0.460

CNS (C70–72)

154,662 (154)

146,523 (173)

1.11 (0.89, 1.40)

0.346

0.185

85,232 (105)

1.23 (0.94, 1.62)

0.129

0.126

Thyroid (C73)

154,590 (82)

146,441 (91)

1.09 (0.80, 1.49)

0.596

0.818

85,179 (52)

0.93 (0.63, 1.38)

0.711

0.789

Non-Hodgkin lymphoma (C82–85, 96)

154,862 (354)

146,772 (422)

1.14 (0.99, 1.32)

0.078

<0.001

85,447 (320)

1.53 (1.30, 1.81)

<0.001

<0.001

Multiple myeloma (C90)

154,670 (163)

146,502 (152)

0.82 (0.65, 1.03)

0.082

0.058

85,211 (84)

0.74 (0.55, 0.98)

0.039

0.029

CLL (C91)

154,675 (167)

146,491 (141)

0.74 (0.58, 0.93)

0.010

0.015

85,205 (78)

0.69 (0.51, 0.92)

0.012

0.006