Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study)

Table 3 Top candidate genes from the two-step correlation analysis

	Probe name	Gene region	Relation to CPG island	Gene symbol	*rho*	P-value	FDR P-value
DNA hypomethylation and positive RNA expression	cg06871213	Body	Nshore	CIITA	−0.3490	0.03002	0.06005
DNA hypomethylation and positive RNA expression	cg04194852	TSS1500	Island	TPM1	−0.3237	0.04493	0.42438
DNA hypermethylation and positive RNA expression (located in gene bodies)	cg04256697	Body;TSS1500;Body	OpenSea	PXN	0.3933	0.01379	0.05514
	cg24112692	Body	OpenSea	ST8SIA1	0.3686	0.02152	0.26539
	cg13931663	Body;Body	OpenSea	LIPA	0.3020	0.06206	0.56834
	cg20618109	Body;Body;TSS1500;Body;Body	N_Shore	DAXX	0.2909	0.07271	0.581641

Correlation of DNA methylation and RNA expression between type 1 diabetes-exposed and controls. Rho is generated from Spearman’s rank correlation analyzing the correlation between the specific methylation level (M-value) and log fold change for shared genes. FDR-adjusted P-value generated using Benjamini-Hochberg correction

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