Table 1 The association between polygenic risk scores (PRSs) for psychiatric disorders and COVID-19
From: Genetic predispositions to psychiatric disorders and the risk of COVID-19
Psychiatric disorders | Any COVID-19 | Severe COVID-19 | ||
|---|---|---|---|---|
Number of cases/total population (%) | Odds ratio | Number of cases/total population (%) | Odds ratio | |
(95% confidence interval)a | (95% confidence interval)a | |||
GWAS summary statistics from UK Biobank base data | ||||
Substance misuse | 10,868/143,562 (7.57%) | 1.03 (1.01–1.05) | 1,582/143,562 (1.10%) | 1.05 (1.00–1.10) |
Depression | 1.03 (1.01–1.05) | 1.05 (0.99–1.10) | ||
Anxiety | 1.03 (1.01–1.05) | 1.02 (0.97–1.07) | ||
Psychotic disorder | 1.00 (0.98–1.02) | 0.96 (0.91–1.01) | ||
Stress-related disorder | 1.00 (0.98–1.02) | 1.01 (0.96–1.06) | ||
GWAS summary statistics from publicly available GWAS summary statistics | ||||
Substance misuse | 21,736/287,123 (7.57%) | 1.03 (1.01–1.04) | 3,146/287,123 (1.10%) | 1.05 (1.01–1.08) |
Depression | 1.02 (1.00–1.03) | 1.03 (1.00–1.07) | ||
Anxiety | 1.01 (1.00–1.03) | 1.05 (1.01–1.08) | ||
Psychotic disorder | 1.01 (0.99–1.02) | 1.01 (0.98–1.05) | ||
Stress-related disorder | 1.02 (1.01–1.03) | 1.08 (1.04–1.11) | ||