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Table 1 The association between polygenic risk scores (PRSs) for psychiatric disorders and COVID-19

From: Genetic predispositions to psychiatric disorders and the risk of COVID-19

Psychiatric disorders Any COVID-19 Severe COVID-19
Number of cases/total population (%) Odds ratio Number of cases/total population (%) Odds ratio
(95% confidence interval)a (95% confidence interval)a
GWAS summary statistics from UK Biobank base data
Substance misuse 10,868/143,562 (7.57%) 1.03 (1.01–1.05) 1,582/143,562 (1.10%) 1.05 (1.00–1.10)
Depression 1.03 (1.01–1.05) 1.05 (0.99–1.10)
Anxiety 1.03 (1.01–1.05) 1.02 (0.97–1.07)
Psychotic disorder 1.00 (0.98–1.02) 0.96 (0.91–1.01)
Stress-related disorder 1.00 (0.98–1.02) 1.01 (0.96–1.06)
GWAS summary statistics from publicly available GWAS summary statistics
Substance misuse 21,736/287,123 (7.57%) 1.03 (1.01–1.04) 3,146/287,123 (1.10%) 1.05 (1.01–1.08)
Depression 1.02 (1.00–1.03) 1.03 (1.00–1.07)
Anxiety 1.01 (1.00–1.03) 1.05 (1.01–1.08)
Psychotic disorder 1.01 (0.99–1.02) 1.01 (0.98–1.05)
Stress-related disorder 1.02 (1.01–1.03) 1.08 (1.04–1.11)
  1. aOdds ratio and 95% confidence interval (an increase of one standard deviation in the corresponding PRS) were estimated by logistic regression models, adjusting for birth year, sex, genotyping array, and significant ancestry principal components (for any COVID-19: PC5, PC9, PC23, PC25, PC26, and PC27, and for severe COVID-19: PC1, PC5, PC9, PC25, PC31, and PC39)