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Table 1 Risk of adverse clinical events and relationship with ABC pathway in clinically complex, frail, multimorbid and polypharmacy patients (n=6091)

From: Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry

  Clinically complex
N=4785
Frailty
N=1175
Multimorbidity
N=4535
Polypharmacy
N=2934
All-cause death
 ABC adherent, vs. non-adherent 0.72 [0.58–0.91] 0.63 [0.38–1.04] 0.71 [0.57–0.89] 0.86 [0.66–1.11]
 1 ABC criteria, vs. 0 0.53 [0.35–0.78] 0.50 [0.32–0.79] 0.51 [0.34–0.76] 0.52 [0.29–0.95]
 2 ABC criteria, vs. 0 0.34 [0.23–0.50] 0.37 [0.23–0.58] 0.32 [0.21–0.47] 0.39 [0.22–0.69]
 3 ABC criteria, vs. 0 0.29 [0.19–0.44] 0.28 [0.15–0.53] 0.27 [0.18–0.42] 0.37 [0.20–0.68]
 For each criteria 0.69 [0.62–0.78] 0.67 [0.56–0.80] 0.68 [0.60–0.76] 0.80 [0.68–0.93]
 2–3 ABC criteria, vs. 0–1 0.56 [0.47–0.68] 0.61 [0.46–0.81] 0.55 [0.45–0.66] 0.68 [0.53–0.88]
MACE
 ABC adherent, vs. non-adherent 0.68 [0.52–0.87] 0.88 [0.54–1.42] 0.69 [0.53–0.88] 0.80 [0.60–1.06]
 1 ABC criteria, vs. 0 0.69 [0.42–1.12] 0.57 [0.33–0.98] 0.64 [0.39–1.06] 0.63 [0.29–1.33]
 2 ABC criteria, vs. 0 0.45 [0.28–0.74] 0.41 [0.23–0.71] 0.44 [0.27–0.71] 0.58 [0.28–1.20]
 3 ABC criteria, vs. 0 0.36 [0.21–0.60] 0.44 [0.22–0.85] 0.35 [0.21–0.58] 0.48 [0.23–1.02]
 For each criteria 0.71 [0.62–0.81] 0.75 [0.61–0.92] 0.71 [0.63–0.82] 0.85 [0.72–1.00]
 2–3 ABC criteria, vs. 0–1 0.59 [0.47–0.73] 0.66 [0.48–0.91] 0.60 [0.48–0.75] 0.83 [0.61–1.12]
Composite outcome
 ABC adherent, vs. non-adherent 0.70 [0.58–0.85] 0.75 [0.50–1.12] 0.70 [0.58–0.85] 0.82 [0.66–1.03]
 1 ABC criteria, vs. 0 0.65 [0.45–0.95] 0.62 [0.40–0.95] 0.61 [0.42–0.90] 0.58 [0.33–1.00]
 2 ABC criteria, vs. 0 0.43 [0.30–0.63] 0.46 [0.30–0.70] 0.41 [0.28–0.59] 0.46 [0.27–0.78]
 3 ABC criteria, vs. 0 0.35 [0.24–0.52] 0.41 [0.24–0.71] 0.33 [0.22–0.49] 0.41 [0.23–0.71]
 For each criteria 0.72 [0.65–0.79] 0.74 [0.63–0.87] 0.71 [0.64–0.79] 0.81 [0.71–0.92]
 2–3 ABC criteria, vs. 0–1 0.59 [0.50–0.70] 0.66 [0.52–0.85] 0.59 [0.50–0.70] 0.72 [0.57–0.90]
  1. Legend: HR [95%CI] adjusted for age, sex, type of AF, hypertension, diabetes, congestive heart failure, coronary artery disease, peripheral artery disease and previous thromboembolism