Fig. 7

Secondary outcomes: Sample type and assay method comparison. A Comparison of concentrations recovered from CVLs to concentrations recovered from other sample types. Each symbol represents one immune mediator. The circles show the mean log2 difference between the indicated sample types and CVLs. B CXCL8 concentrations recovered by sample type. Each box plot shows a single study, colored by sample type in that study, with menstrual cup shown in red, sponge shown in blue, swab shown in green, and CVL shown in white. The studies are sorted by median concentration. C Comparison of concentrations recovered from 10 mL CVLs to concentrations recovered from 5 mL CVLs. Each symbol represents one immune mediator. The circles show the mean log2 difference between 5 and 10 mL CVLs. D CXCL8 concentrations recovered by CVL volume. Each box plot shows a single study, colored by CVL volume in that study, with 5 mL shown in grey and 10 mL shown in white. The studies are sorted by median concentration. E Comparison of concentrations detected by ELISA to concentrations detected by other assays. Each symbol represents one immune mediator. The circles show the mean log2 difference between the indicated assays and ELISAs. F CXCL8 concentrations measured by assay type. Each box plot shows a single study, colored by assay type in that study, with Luminex shown in green, MSD shown in orange, and ELISA shown in white. The studies are sorted by median concentration