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Table 4 Summary of primary meta-analyses (logistic models)

From: Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Category

Immune mediator

Name

Log2 difference

Standard error

P-value

FDR

Holm-Bonferroni

I2

Number of studies

GRADE

Chemokine CX-type

CXCL12 | SDF-1β

C-X-C motif chemokine ligand 12

− 1.01

0.35

0.004

0.008

0.008

0

2

Low

Interleukin 2 family

IL-15

interleukin 15

− 0.77

0.54

0.155

0.155

0.155

70

4

Low

  1. Logistic fold change, difference between phases (log-odds of proportion detectable in luteal vs. follicular phase) with positive numbers indicating higher concentrations in the luteal phase (relative to the follicular phase) and negative numbers indicating lower concentrations in the luteal phase (relative to the follicular phase); FDR False discovery rate, I2 statistical heterogeneity between studies, from low (0) to high (100), GRADE Grading of Recommendations, Assessment, Development and Evaluations strength of evidence framework (very low, low, moderate, high)