A differentiated digital intervention to improve antiretroviral therapy adherence among men who have sex with men living with HIV in China: a randomized controlled trial

Table 2 Effect of differentiated digital intervention on secondary outcomes using ITT analysis among MSM living with HIV in China, 2020–2021

	Differentiated digital intervention (Total)	Text message-based intervention	Instant message-based intervention	Instant message plus social media group intervention
Outcomes	RR (95%CI)
Viral suppression^a	1.39 (0.64, 3.05)	1.28 (0.15, 10.59)	0.85 (0.27, 2.62)	3.06 (0.70, 13.33)
	MD (95%CI)
CD4 T cell counts	− 1.55 (− 17.51, 14.42)	− 10.67 (− 39.38, 18.04)	6.98 (− 14.87, 28.84)	− 5.81 (− 42.58, 30.95)
HIV treatment adherence self-efficacy	1.41 (− 0.09, 2.92)	1.24 (− 1.55, 4.02)	1.67 (− 0.26, 3.61)	0.27 (− 3.45, 3.99)
Quality of life	0.47 (− 0.43, 1.36)	− 1.50 (− 3.24, 0.25)	0.85 (− 0.43, 2.13)	1.66 (− 0.16, 3.47)

Abbreviations: ITT intention-to-treat, RR risk ratio, MD mean difference, CI confidence interval, MSM men who have sex with men
^aDefined as undetectable viral load (i.e., < 20 copies/ml)

ISSN: 1741-7015