Influence of baseline arterial stiffness on effects of intensive compared with standard blood pressure control: a post hoc analysis of the STEP trial

Table 2 Effects of SBP intervention on cardiovascular outcomes within AS and non-AS groups via multivariable Cox proportional hazard regression

Multivariable model was adjusted for clinical centers, age, and sex, baseline MAP level, baseline glucose level, baseline LDL cholesterol level, baseline antihypertensive agent type, physical activity frequency, smoking status, and drinking status. Missing values of physical activity frequency, smoking status, drinking status (n = 17, 0.26%), baseline glucose level (n=214, 3.12%), baseline LDL cholesterol level (n=178, 2.59%) were added via multiple imputation
Abbreviations: AS arterial stiffness, SBP systolic blood pressure, CI confidence interval, ACS acute coronary syndrome, MACE major adverse cardiac events
^*P for interaction was calculated by the multiplicative interaction between the baseline AS and non-AS groups and SBP intervention for the incidence of primary and secondary outcomes
^aPrimary outcome contains the first occurrence of stroke (ischemic or hemorrhagic), acute coronary syndrome (myocardial infarction and hospitalization for unstable angina), acute decompensated heart failure, coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting), atrial fibrillation, or death of cardiovascular causes
^bMACE was a composite of first occurrence of acute coronary syndrome, acute decompensated heart failure, coronary revascularization, and death of cardiovascular causes

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