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Table 3 Effect of baseline baPWV and SBP intervention on the incidence of low on-treatment DBP (<70 mmHg)

From: Influence of baseline arterial stiffness on effects of intensive compared with standard blood pressure control: a post hoc analysis of the STEP trial

Intervention

On-treatment DBP <70 mmHg

% On-treatment DBP <70 mmHg

Odds ratio (95% CI)

Univariable model

P value

Multivariable model

P value

Intensive treatment

Non-AS

122/1760

6.93

Reference

0.87

Reference

0.82

AS

92/1299

7.08

1.02 (0.77–1.35)

0.96 (0.71–1.32)

Standard treatment

Non-AS

29/1631

1.78

Reference

0.005

Reference

0.10

AS

48/1407

3.41

1.95 (1.23–3.14)

1.56 (0.92–2.63)

P for interaction*

  

0.02

 

0.07

 
  1. Multivariable model was adjusted for clinical centers, age, and sex, baseline MAP level, baseline glucose level, baseline LDL cholesterol level, baseline antihypertensive agent type, physical activity frequency, smoking status, and drinking status. Missing values of physical activity frequency, smoking status, drinking status (n = 17, 0.26%), baseline glucose level (n=214, 3.12%), baseline LDL cholesterol level (n=178, 2.59%) were added via multiple imputation
  2. Abbreviations: baPWV brachial-ankle pulse wave velocity, SBP systolic blood pressure, DBP diastolic blood pressure, MAP Mean arterial pressure, CI confidence interval, AS arterial stiffness, LDL low-density lipoprotein
  3. *P for interaction was calculated by the multiplicative interaction between the baseline AS and non-AS groups and SBP intervention for the incidence of DBP < 70 mmHg