Table 2 Median number and range of all molecular alterations that were reported to both MTB for clinical interpretation in the WES and RNA-Seq and WES only groups
Molecular characteristics | WES + RNA-seq n = 38 | WES n = 3 |
|---|---|---|
Aberrations, no. | ||
Median (range) | 309 (181–6013) | 82 (24–9248) |
Single nucleotide variants, no. | ||
Somatic median (range) | 48.5 (2–5645) | 73 (22–9139) |
Germline median (range) | 1 (0–5) | 1 (0–3) |
Indels, no. | ||
Somatic median (range) | 3 (0–21) | 6 (2–107) |
Germline median (range) | 0 (0–2) | 0 (0–1) |
Structural variants, no. | ||
Median (range) | 99.5 (5–731) | 61 (53–426) |
Gene fusions, no. | ||
Median (range) | 83 (0–663) | N/A |
Gene expression outlier, no. | ||
Median (range) | 166 (105–393) | N/A |