From: Metabolomic profile of prostate cancer-specific survival among 1812 Finnish men
Chemical sub-class pathway | Pathway analysis | PCA analysis for pattern score (by quartiles) b | |||||
---|---|---|---|---|---|---|---|
No. of contributing metabolites | P-value | Q1 | Q2 | Q3 | Q4 | P-value c | |
Referent | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
Endocannabinoids | 10 | <10−5 | 1.00 | 1.25 (0.94, 1.67) | 1.54 (1.16, 2.04) | 1.92 (1.46, 2.51) | 4.5×10−7 |
Glycine, serine, and threonine metabolism | 10 | <10−5 | 1.00 | 1.22 (0.92, 1.63) | 1.43 (1.08, 1.88) | 1.92 (1.47, 2.51) | 6.5×10−7 |
Gamma-glutamyl amino acids | 18 | <10−5 | 1.00 | 1.30 (0.97, 1.72) | 1.26 (0.94, 1.69) | 1.94 (1.49, 2.52) | 9.5×10−7 |
Glutamate metabolism | 13 | <10−5 | 1.00 | 1.14 (0.87, 1.51) | 1.39 (1.05, 1.83) | 1.71 (1.32, 2.23) | 1.5×10−5 |
Eicosanoid | 3 | <10−5 | 1.00 | 0.93 (0.70, 1.25) | 1.22 (0.93, 1.60) | 1.62 (1.25, 2.10) | 1.8×10−5 |
Sphingolipid synthesis | 3 | <10−5 | 1.00 | 1.08 (0.81, 1.44) | 1.36 (1.03, 1.78) | 1.61 (1.24, 2.08) | 5.5×10−5 |
Glutathione metabolism | 7 | <10−5 | 1.00 | 0.59 (0.46, 0.75) | 0.63 (0.49, 0.80) | 0.62 (0.48, 0.79) | 1.7×10−4 |
Dipeptides | 6 | <10−5 | 1.00 | 1.17 (0.87, 1.56) | 1.08 (0.81, 1.45) | 1.65 (1.27, 2.15) | 2.0×10−4 |