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Table 2 Results were obtained for the generalized linear models used with the (i) clinical variables, (ii) metabolites, and (iii) clinical variables and metabolites. * means statistically significant

From: Metabolomics analysis of type 2 diabetes remission identifies 12 metabolites with predictive capacity: a CORDIOPREV clinical trial study

  

Estimate

Std. error

z value

Pr( >|z|)

Clinical variables

Intercept

 − 0.43249

0.18301

 − 2.363

0.0181*

Sex

 − 0.08264

0.16283

 − 0.508

0.6118

Age baseline

0.09660

0.16102

0.600

0.5486

HDL Imputed

0.10651

0.16663

0.639

0.5227

TG Imputed

 − 0.27225

0.17275

 − 1.576

0.1150

BMI baseline

0.44999

131.228

0.343

0.7317

Intensity statin therapy

 − 0.11911

0.15505

 − 0.768

0.4424

Metabolites

Intercept

 − 0.459189

0.704513

 − 0.652

0.5145

Sphingosine (d18:2)

 − 0.107924

0.260230

 − 0.415

0.6783

Docosenamide

0.004636

0.004572

1.014

0.3106

Oxo-tricosanoic acid

 − 0.002283

0.003195

 − 0.714

0.4750

Tetracosahexaenoic acid

 − 0.003083

0.003112

 − 0.991

0.3219

Ketodeoxycholic acid

 − 0.293914

0.290994

 − 1.010

0.3125

Stearoylcarnitine

 − 0.436030

0.230849

 − 1.889

0.0589

Diglyceride (33:4)

0.194136

0.198864

0.976

0.3290

Creatine

 − 0.001211

0.003222

 − 0.376

0.7071

Tridecanoic acid

 − 0.001950

0.003332

 − 0.585

0.5584

Monoacylglycerol (22:6)

0.003391

0.003096

1.095

0.2733

Dihydroxycholesterol

 − 0.327887

0.177616

 − 1.846

0.0649

Biliverdin

 − 0.362871

0.179566

 − 2.021

0.0433*

Clinical variables and metabolites

Intercept

 − 0.330027

0.726670

 − 0.454

0.6497

Sphingosine (d18:2)

 − 0.042235

0.271197

 − 0.156

0.8762

Docosenamide

0.004359

0.004724

0.923

0.3561

Oxo-tricosanoic acid

 − 0.002246

0.003257

 − 0.689

0.4905

Tetracosahexaenoic acid

 − 0.004089

0.003290

 − 1.243

0.2139

Ketodeoxycholic acid

 − 0.321368

0.302763

 − 1.061

0.2885

Stearoylcarnitine

 − 0.461926

0.236503

 − 1.953

0.0508

Diglyceride (33:4)

0.184457

0.208359

0.885

0.3760

Creatine

 − 0.001613

0.003291

 − 0.490

0.6241

Tridecanoic acid

 − 0.001681

0.003458

 − 0.486

0.6268

Monoacylglycerol (22:6)

0.003439

0.003158

1.089

0.2761

Dihydroxycholesterol

 − 0.307896

0.182783

 − 1.684

0.0921

Biliverdin

 − 0.348474

0.181466

 − 1.920

0.0548

Sex

 − 0.091159

0.178688

 − 0.510

0.6099

Age baseline

0.142588

0.177915

0.801

0.4229

HDL Imputed

0.053527

0.188053

0.285

0.7759

TG Imputed

 − 0.223763

0.185640

 − 1.205

0.2281

BMI baseline

0.402986

1.322.298

0.305

0.7605

Intensity Statin Therapy

 − 0.214802

0.174998

 − 1.227

0.2197