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Table 1 Characteristics of 61,437 internal medicine inpatients aged 18 years or older and fasting for more than 10 daysa in Japan, January 2011 to September 2020

From: Clinical impact of lipid injectable emulsion in internal medicine inpatients exclusively receiving parenteral nutrition: a propensity score matching analysis from a Japanese medical claims database

Variables

Before PSM

After PSM

Non-ILE group (n = 41,819)

ILE group (n = 19,618)

Standardized difference, %

Non-ILE group (n = 19,602)

ILE group (n = 19,602)

Standardized difference, %

Age (years)

  18–59

6888 (16.5)

3415 (17.4)

− 4.4

3420 (17.4)

3411 (17.4)

0.1

  60–69

8073 (19.3)

3747 (19.1)

 

3762 (19.2)

3744 (19.1)

 

  70–79

11,097 (26.5)

5429 (27.7)

 

5407 (27.6)

5427 (27.7)

 

  80–89

11,596 (27.7)

5437 (27.7)

 

5417 (27.6)

5431 (27.7)

 

  > 90

4165 (10.0)

1590 (8.1)

 

1596 (8.1)

1589 (8.1)

 

Sex

  Male

22,131 (52.9)

11,453 (58.4)

− 11.0

11,475 (58.5)

11,439 (58.4)

0.4

  Female

19,688 (47.1)

8165 (41.6)

 

8127 (41.5)

8163 (41.6)

 

Body mass index (kg/m2)

  <16

5350 (12.8)

2793 (14.2)

− 6.3

2797 (14.3)

2790 (14.2)

− 0.1

  16–18.5

9193 (22.0)

4516 (23.0)

 

4464 (22.8)

4513 (23.0)

 

  18.5–22.5

16,613 (39.7)

7673 (39.1)

 

7680 (39.2)

7668 (39.1)

 

  22.5–25

6050 (14.5)

2712 (13.8)

 

2758 (14.1)

2709 (13.8)

 

  25–30

3847 (9.2)

1650 (8.4)

 

1642 (8.4)

1648 (8.4)

 

  ≥ 30

766 (1.8)

274 (1.4)

 

261 (1.3)

274 (1.4)

 

Number of hospital beds

  < 200

4156 (9.9)

1880 (9.6)

6.5

1848 (9.4)

1879 (9.6)

− 0.6

  200–500

23,247 (55.6)

10,246 (52.2)

 

10,226 (52.2)

10,236 (52.2)

 

  ≥ 500

14,416 (34.5)

7492 (38.2)

 

7528 (38.4)

7487 (38.2)

 

Year of admission

  2011–2012

3698 (8.8)

1571 (8.0)

5.6

1577 (8.0)

1571 (8.0)

0.3

  2013–2014

7603 (18.2)

3305 (16.8)

 

3309 (16.9)

3304 (16.9)

 

  2015–2016

10,543 (25.2)

4854 (24.7)

 

4885 (24.9)

4850 (24.7)

 

  2017–2019

11,459 (27.4)

5663 (28.9)

 

5621 (28.7)

5658 (28.9)

 

  2019–2020

8516 (20.4)

4225 (21.5)

 

4210 (21.5)

4219 (21.5)

 

Type of admission

  Elective

23,287 (55.7)

11,293 (57.6)

− 0.6

11,212 (57.2)

11,284 (57.6)

− 0.2

  Emergency

18,505 (44.3)

8315 (42.4)

 

8379 (42.7)

8308 (42.4)

 

  NA

27 (0.1)

10 (0.1)

 

11 (0.1)

10 (0.1)

 

Primary disease

  Digestive system malignancy

10,645 (25.5)

6733 (34.3)

− 8.9

6798 (34.7)

6723 (34.3)

0.6

  Hematological malignancy

1647 (3.9)

324 (1.7)

 

302 (1.5)

324 (1.7)

 

  Other malignancies

3156 (7.5)

998 (5.1)

 

1001 (5.1)

998 (5.1)

 

  Sepsis

675 (1.6)

233 (1.2)

 

231 (1.2)

233 (1.2)

 

  Coagulopathy disease

337 (0.8)

112 (0.6)

 

117 (0.6)

111 (0.6)

 

  Cerebrovascular disease

1600 (3.8)

413 (2.1)

 

417 (2.1)

413 (2.1)

 

  Cardiovascular disease

1501 (3.6)

486 (2.5)

 

450 (2.3)

486 (2.5)

 

  Respiratory disease

6057 (14.5)

2812 (14.3)

 

2785 (14.2)

2808 (14.3)

 

  Digestive system disease

9556 (22.9)

4866 (24.8)

 

4879 (24.9)

4865 (24.8)

 

  Kidney and urinary tract disease

1065 (2.5)

439 (2.2)

 

453 (2.3)

439 (2.2)

 

  Others

5580 (13.3)

2202 (11.2)

 

2169 (11.1)

2202 (11.2)

 

Charlson Comorbidity Index

  0

16,361 (39.1)

7255 (37.0)

2.2

241 (36.9)

7253 (37.0)

− 0.2

  1

1447 (3.5)

619 (3.2)

 

625 (3.2)

619 (3.2)

 

  2

14,532 (34.7)

7677 (39.1)

 

7630 (38.9)

7663 (39.1)

 

  ≥ 3

9479 (22.7)

4067 (20.7)

 

4106 (20.9)

4067 (20.7)

 

Barthel Index

  100

15,111 (36.1)

8636 (44.0)

− 16.0

8696 (44.4)

8625 (44.0)

0.6

  65–95

4022 (9.6)

1897 (9.7)

 

1909 (9.7)

1897 (9.7)

 

  45–60

2694 (6.4)

1181 (6.0)

 

1154 (5.9)

1181 (6.0)

 

  25–40

1459 (3.5)

586 (3.0)

 

588 (3.0)

584 (3.0)

 

  5–20

2510 (6.0)

1050 (5.4)

 

1017 (5.2)

1050 (5.4)

 

  0

11,104 (26.6)

4230 (21.6)

 

4204 (21.4)

4228 (21.6)

 

  NA

4919 (11.8)

2038 (10.4)

 

2034 (10.4)

2037 (10.4)

 

Japan Coma Scale

  0

31,781 (76.0)

15,775 (80.4)

− 11.5

15,780 (80.5)

15,763 (80.4)

0.8

  1–3

5414 (12.9)

2266 (11.6)

 

2308 (11.8)

2263 (11.5)

 

  10–30

2269 (5.4)

808 (4.1)

 

778 (4.0)

808 (4.1)

 

  100–300

1213 (2.9)

399 (2.0)

 

393 (2.0)

399 (2.0)

 

  NA

1142 (2.7)

370 (1.9)

 

343 (1.7)

369 (1.9)

 

Nutritional statusb

  Malnutrition

18,855 (45.1)

9242 (47.1)

4.1

9225 (47.1)

9234 (47.1)

0.1

Medical treatmentc

  Albumin infusion

3498 (8.4)

2287 (11.7)

11.0

2235 (11.4)

2280 (11.6)

0.8

  Blood transfusion

7145 (17.1)

3418 (17.4)

0.9

3435 (17.5)

3412 (17.4)

− 0.3

  Respirator use

1605 (3.8)

1007 (5.1)

6.3

990 (5.1)

1002 (5.1)

0.3

  Dialysis

331 (0.8)-

200 (1.0)

2.4

197 (1.0)

199 (1.0)

0.1

  Nutrition support teamd

2268 (5.4)

2170 (11.1)

20.6

1921 (9.8)

2157 (11.0)

4.4

  Rehabilitation

13,397 (32.0)

7032 (35.8)

8.1

6882 (35.1)

7023 (35.8)

1.5

PN duration, mean (SD), days

25.1 (30.3)

23.0 (24.3)

− 7.6

24.5 (26.7)

23.0 (24.3)

− 5.4

  1. Data presented as numbers of patients (percentages), unless otherwise indicated
  2. Abbreviations: ILE, lipid injectable emulsion (soybean oil-based); NA, not available; PSM, propensity score matching; PN, parenteral nutrition; BMI, body mass index
  3. aDay 1 regarded as the day fasting started
  4. bMalnutrition defined as phenotype criteria (BMI < 18.5 if < 70 years old or < 20 if > 70 years old) as well as etiologic criteria (fasting for more than 10 days), based on the GLIM criteria for Asian populations [12]
  5. cFrom the day of admission to day 10
  6. dIntervention by the nutrition support team