From: Heterogeneity in pragmatic randomised trials: sources and management
Patients: Adults with depression Centres: General medical practices Interventions: Acupuncture and counselling Control: Usual care Outcome: Depression prevalence assessed with the Patient Health Questionnaire 9 at 3 months Design: Three parallel-group individually randomised trial | |
Statistical analysis | “Multiple imputation by chained regression was used for missing data using treatment group, baseline measures (PHQ-9, BDI-II, SF-36, EQ-5D Anxiety/Depression), and demographics (age and gender). The primary analysis was based on the imputed rather than raw data in order to take account of the profile of non-responders.” |