Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study

Table 1 Characteristics of the ALS and autoimmune disease GWAS cohorts and results of the power analysis

Disease	Study	Journal	Cases	Controls	Sample size	Min OR MR	Min OR reverse MR
ALS	van Rheenen et al. [23]	Nat. Genet.	27,205	110,881	138,086	–	–
Asthma	Valette et al. [25]	Commun. Biol.	56,167	352,255	408,422	1.700	1.270
CD	M. de Lange et al. [26]	Nat. Genet.	12,194	28,072	40,266	1.260	1.730
CeD	Trynka et al. [27]	Nat. Genet.	12,041	12,228	24,269	1.234	1.190
IBS	Eijsbouts et al. [28]	Nat. Genet.	40,548	293,220	333,768	2.000	1.320
MS	Consortium I.M.S.G., et al. [29]	Science.	47,429	68,374	115,803	1.28	1.510
PBC	Cordell et al. [30]	J. Hepatol.	8021	16,489	24,510	1.190	2.000
PSC	Ji et al. [31]	Nat. Genet.	2871	12,019	14,890	1.180	2.370
PsO	Tsoi et al. [32]	Nat. Genet.	10,588	22,806	33,394	1.045	1.600
RA	Okada et al. [33]	Nature	19,234	61,565	80,799	1.380	1.500
T1D	Forgetta et al. [34]	Diabetes	9266	15,584	24,840	1.180	1.950
UC	M. de Lange et al. [26]	Nat. Genet.	12,366	33,609	45,975	1.290	1.700
SLE	Bentham et al. [35]	Nat. Genet.	5201	9066	14,267	1.440	1.510

Min OR MR minimum OR in the main MR for a power of 80%, Min OR reverse MR minimum OR in reverse MR for a power of 80%, CD Crohn’s disease, CeD celiac disease, IBS irritable bowel syndrome, MS multiple sclerosis, PBC primary biliary cirrhosis, PSC primary sclerosing cholangitis, PsO psoriasis, RA rheumatoid arthritis, T1D type 1 diabetes, UC ulcerative colitis, SLE systemic lupus erythematosus

ISSN: 1741-7015