Fig. 3

Visual representation of target product profile matching for candidates to prevent pre-eclampsia. A traffic light system to visualise each candidate for pre-eclampsia prevention at A phase III, B phase II and C phase I clinical development. Candidates are classified as met preferred (dark green), met minimum (light green), partially met minimum (yellow) and did not meet the minimum (red) requirements in the target product profiles. When insufficient information is available for a specific variable, they have been classified as not yet known (grey). *Target country is classified as trials being conducted in HIC and LMIC (dark green), HIC only or LMIC only (both yellow) or country not stated (grey). **Stability has been classified as does not require cold chain (green), requires cold chain (red) or unsure (grey). #WHO EML is classified as the candidate is already on the WHO EML list (green) or the candidate is not on the WHO EML list (red). The final rank has been determined by quantification of the matching to the target product profiles (see Additional file 1: tables S3 and S4 for details of quantification coding), with efficacy and safety given a greater weight than other variables. HIC high-income country, LMIC low- or middle-income country, EML essential medicines list