Table 1 C-statistics for coronary artery disease for full population and stratified by sex and age group (younger and older than 55 years of age)A,B
From: Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease
C-statistic (95% CI) | ||||||
|---|---|---|---|---|---|---|
|  | All | Men | Women | Participants aged < 55 y | Participants aged ≥ 55 y | Participants not receiving lipid-lowering treatment at baseline |
A. White British ancestry | ||||||
 Participants, no | 272,307 | 124,155 | 148,152 | 102,330 | 169,977 | 235,172 |
 Cases, no | 7036 | 5093 | 1943 | 1276 | 5760 | 5091 |
 Polygenic risk score | .64 (.634–.646) | .643 (.636–.651) | .641 (.629–.654) | .69 (.626–.705) | .632 (.625–.639) | .646 (.638–.653) |
 Pooled cohort equation | .718 (.713–.723) | .663 (.656–.67) | .706 (.695–.717) | .749 (.736–.761) | .665 (.658–.671) | .73 (.724–.737) |
 Polygenic risk score + pooled cohort equation | .753 (.748–.758) | .714 (.708–.721) | .741 (.73–.751) | .793 (.781–.806) | .705 (.699–.712) | .766 (.76–.772) |
B. African ancestry | ||||||
 Participants, no | 6753 | 2901 | 3852 | 4528 | 2225 | 5896 |
 Cases, no | 88 | 46 | 42 | 42 | 46 | 63 |
 Polygenic risk score | .542 (.485–.6) | .574 (.494–.654) | .6 (.511–.634) | .548 (.46–.637) | .543 (.462–.624) | .534 (.464–.604) |
 Pooled cohort equation | .714 (.659–.769) | .674 (.595–.753) | .734 (.653–.815) | .657 (.572–.742) | .721 (.656–.787) | .698 (.628–.768) |
 Polygenic risk score + pooled cohort equation | .716 (.665–.768) | .695 (.622–.768) | .732 (.654–.81) | .679 (.597–.761) | .696 (.629–.763) | .707 (.64–.774) |