Index condition | Routine care | Aggregate data trials N=483 | IPD trials N=125 | |||||
---|---|---|---|---|---|---|---|---|
Total N | Mean age (sd) | Included trials | Total number of participants | Range of mean trial age | Included trials | Total number of participants | Range of mean trial age | |
Asthma | 191,160 | 45.6 (22.9) | 47 | 74,833 | 35.2–51.4 | 4 | 1084 | 32.0–50.2 |
Atrial fibrillation | 43,330 | 74.7 (11.9) | 9 | 12,539 | 59.3–75.0 | 1 | 18,113 | 72.8 |
Axial spondyloarthritis | 1982 | 52.4 (15.3) | 8 | 2994 | 29.9–45.2 | 2 | 320 | 38.0–43.8 |
Benign prostatic hyperplasia | 19,906 | 72.0 (10.0) | 7 | 4617 | 60.9–66.5 | 5 | 1710 | 62.2–66.6 |
Chronic obstructive pulmonary disease | 57,378 | 69.1 (11.6) | 94 | 131,630 | 61.1–70.8 | 7 | 3376 | 61.0–66.1 |
Dementia | 13,871 | 82.1 (9.0) | 3 | 2506 | 73.8–74.4 | 6 | 4791 | 69.0–83.0 |
Epilepsy | 29,554 | 45.8 (21.0) | 8 | 3715 | 32.2–41.1 | 0 | - |  |
Hypertension | 310,691 | 67.0 (12.9) | 14 | 10,380 | 49.2–70.7 | 12 | 6863 | 51.4–70.9 |
Inflammatory bowel disease | 12514 | 52.3 (17.8) | 7 | 4086 | 37.4–44.7 | 10 | 4352 | 36.0–41.9 |
Myocardial infarction | 3510 | 70.7 (14.1) | 11 | 76,425 | 58.2–67.0 | 0 | - |  |
Osteoarthritis | 124,521 | 67.6 (12.7) | 4 | 1794 | 60.7–62.7 | 1 | 1321 | 63.9 |
Osteoporosis | 38,212 | 72.8 (12.2) | 5 | 5335 | 68.8–74.8 | 7 | 51,204 | 53.6–73.2 |
Parkinson’s disease | 4998 | 74.9 (10.4) | 14 | 5754 | 61.9–67.5 | 4 | 1212 | 61.0–62.9 |
Psoriasis | 52,810 | 49.1 (19.0) | 24 | 19,064 | 43.1–54.2 | 7 | 3609 | 43.6–46.0 |
Psoriatic arthropathy | 3523 | 54.1 (14.0) | 13 | 5168 | 47.4–51.9 | 3 | 596 | 45.9–49.0 |
Pulmonary fibrosis | 1465 | 73.3 (10.9) | 4 | 1962 | 66.6–70.3 | 2 | 1063 | 66.2–67.7 |
Pulmonary hypertension | 759 | 60.5 (27.0) | 2 | 1757 | 48.1–55.7 | 1 | 161 | 52.2 |
Rheumatoid arthritis | 13,809 | 62.2 (15.5) | 29 | 21,545 | 46.6–60.7 | 11 | 5223 | 49.0–55.6 |
Systemic lupus erythematosus | 1033 | 52.8 (15.5) | 3 | 1998 | 32.1–41.3 | 2 | 1129 | 33.6–39.8 |
Thromboembolism | 9162 | 66.1 (15.7) | 4 | 8503 | 40.0–76.4 | 7 | 16,959 | 53.3–55.7 |
Type 2 diabetes mellitus | 82,473 | 65.3 (13.0) | 173 | 239,662 | 48.8–74.2 | 23 | 19,830 | 53.5–64.1 |