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Table 1 Description of numbers of people in community and participants in trials for each index condition

From: Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data

Index condition

Routine care

Aggregate data trials N=483

IPD trials N=125

Total N

Mean age (sd)

Included trials

Total number of participants

Range of mean trial age

Included trials

Total number of participants

Range of mean trial age

Asthma

191,160

45.6 (22.9)

47

74,833

35.2–51.4

4

1084

32.0–50.2

Atrial fibrillation

43,330

74.7 (11.9)

9

12,539

59.3–75.0

1

18,113

72.8

Axial spondyloarthritis

1982

52.4 (15.3)

8

2994

29.9–45.2

2

320

38.0–43.8

Benign prostatic hyperplasia

19,906

72.0 (10.0)

7

4617

60.9–66.5

5

1710

62.2–66.6

Chronic obstructive pulmonary disease

57,378

69.1 (11.6)

94

131,630

61.1–70.8

7

3376

61.0–66.1

Dementia

13,871

82.1 (9.0)

3

2506

73.8–74.4

6

4791

69.0–83.0

Epilepsy

29,554

45.8 (21.0)

8

3715

32.2–41.1

0

-

 

Hypertension

310,691

67.0 (12.9)

14

10,380

49.2–70.7

12

6863

51.4–70.9

Inflammatory bowel disease

12514

52.3 (17.8)

7

4086

37.4–44.7

10

4352

36.0–41.9

Myocardial infarction

3510

70.7 (14.1)

11

76,425

58.2–67.0

0

-

 

Osteoarthritis

124,521

67.6 (12.7)

4

1794

60.7–62.7

1

1321

63.9

Osteoporosis

38,212

72.8 (12.2)

5

5335

68.8–74.8

7

51,204

53.6–73.2

Parkinson’s disease

4998

74.9 (10.4)

14

5754

61.9–67.5

4

1212

61.0–62.9

Psoriasis

52,810

49.1 (19.0)

24

19,064

43.1–54.2

7

3609

43.6–46.0

Psoriatic arthropathy

3523

54.1 (14.0)

13

5168

47.4–51.9

3

596

45.9–49.0

Pulmonary fibrosis

1465

73.3 (10.9)

4

1962

66.6–70.3

2

1063

66.2–67.7

Pulmonary hypertension

759

60.5 (27.0)

2

1757

48.1–55.7

1

161

52.2

Rheumatoid arthritis

13,809

62.2 (15.5)

29

21,545

46.6–60.7

11

5223

49.0–55.6

Systemic lupus erythematosus

1033

52.8 (15.5)

3

1998

32.1–41.3

2

1129

33.6–39.8

Thromboembolism

9162

66.1 (15.7)

4

8503

40.0–76.4

7

16,959

53.3–55.7

Type 2 diabetes mellitus

82,473

65.3 (13.0)

173

239,662

48.8–74.2

23

19,830

53.5–64.1