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Fig. 4 | BMC Medicine

Fig. 4

From: Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Fig. 4

Dynamic changes in CSF ctDNA concentration better predict intracranial tumor response than plasma. Kaplan-Meier curves of intracranial progression-free survival (A) and extracranial progression-free survival (B) between patients with and without CSF ctDNA response. Kaplan-Meier curves of intracranial progression-free survival (C) and extracranial progression-free survival (D) between patients with and without plasma ctDNA response. P-values were calculated using the log-rank test. Abbreviations: CSF, cerebrospinal fluid; ctDNA, circulating tumor DNA; HR, hazards ratio; PFS, progression-free survival

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