Table 1 In-trial cost-effectiveness results
Outcomes | Enalapril-folic acid (n = 10348) | Enalapril (n = 10354) | ∆ (Enalapril-folic acid–Enalapril) (95%CI) | P value |
|---|---|---|---|---|
Enalapril/enalapril-folic acid cost ($/￥) | $1170.46 ￥7549.47 | $137.41 ￥886.29 | $1033.05 (1029.51 to 1036.59) ￥6663.18 (6640.35 to 6686.01) | < 0.001 |
Concomitant drug cost ($/￥) | $75.13 ￥484.60 | $73.01 ￥470.91 | $2.12 (− 2.20 to 6.44) ￥13.69 (− 14.16 to 41.54) | 0.335 |
Stroke-related costs ($/ï¿¥) | ||||
 Ischemic stroke | $32.95 ￥212.55 | $43.13 ￥278 .16 | $− 10.17 (− 16.66 to − 3.68) ￥− 65.61 (− 107.45 to − 23.76) | 0.002 |
 Hemorrhagic stroke | $17.98 ￥115.96 | $19.21 ￥123.88 | $− 1.23 (− 7.86 to 5.41) ￥− 7.93 (− 50.72 to 34.87) | 0.717 |
Other CVD-related costs ($/￥) | $10.89 ￥70.25 | $9.98 ￥64.36 | $0.91 (− 5.11 to 6.94) ￥5.89 (− 32.97 to 44.75) | 0.766 |
Total costs ($/￥) | $923.74 ￥5958.14 | $217.71 ￥1404.22 | $706.03 (695.28 to 716.79) ￥4553.92 (4484.56 to 4623.27) | < 0.001 |
QALY | 3.92 | 3.90 | 0.016 (− 0.001 to 0.033) | 0.064 |
ICER ($/QALY)/(ï¿¥/QALY) | $44,127.13 ï¿¥284,620 | |||