| HAIC 2d (n=120) |  | HAIC 1d (n=248) |  | p | p for grade 3–4 AE | ||||
---|---|---|---|---|---|---|---|---|---|---|
Any grade | Grades 1–2 | Grade 3 | Grade 4 | Any grade | Grades 1–2 | Grade 3 | Grade 4 |  |  | |
Hypertension | 44 (36.7%) | 43 (36.2%) | 1 (0.95%) | 0 | 83 (33.5%) | 79 (31.9%) | 4 (1.6%) | 0 | 0.55 | 1 |
Fatigue | 87 (72.4%) | 87 (72.4%) | 0 | 0 | 99 (39.9%) | 98 (39.5%) | 1 (0.4%) | 0 | <0.001 | 1 |
Fever | 16 (13.3%) | 16 (13.3%) | 0 | 0 | 19 (7.7%) | 19 (7.7%) | 0 | 0 | 0.082 | Â |
Sensory neuropathy | 46 (38.1%) | 46 (38.1%) | 0 | 0 | 28 (11.3%) | 27 (10.9%) | 1 (0.4%) | 0 | <0.001 | 1 |
Edema | 15 (12.4%) | 15 (12.4%) | 0 | 0 | 21 (8.5%) | 17 (6.9%) | 4 (1.6%) | 0 | 0.22 | 0.31 |
Alopecia | 23 (19.1%) | 23 (19.1%) | 0 | 0 | 10 (4.0%) | 10 (4.0%) | 0 | 0 | <0.001 | Â |
Abdominal pain | 70 (58.1%) | 69 (57.1%) | 1 (0.95%) | 0 | 128 (51.6%) | 121 (48.8%) | 5 (2.0%) | 2 (0.8%) | 0.23 | 0.4 |
Nausea | 91 (76.2%) | 89 (74.3%) | 2 (1.9%) | 0 | 140 (56.5%) | 137 (55.2%) | 3 (1.2%) | 0 | <0.001 | 0.66 |
Vomit | 49 (41.0%) | 41 (34.3%) | 8 (6.7%) | 0 | 75 (30.2%) | 61 (24.6%) | 14 (5.7%) | 0 | 0.044 | 0.7 |
Diarrhea | 31 (25.7%) | 26 (21.9%) | 5 (3.8%) | 0 | 38 (15.3%) | 38 (15.3%) | 0 | 0 | 0.015 | 0.003 |
Neutropenia | 21 (17.5%) | 19 (16.2%) | 1 (0.95%) | 1 (0.95%) | 16 (6.5%) | 13 (5.2%) | 2 (0.8%) | 1 (0.4%) | 0.001 | 0.66 |
Anemia | 83 (69.5%) | 82 (68.6%) | 1 (0.95%) | 0 | 145 (58.5%) | 145 (58.5%) | 0 | 0 | 0.048 | 0.33 |
Thrombocytopenia | 58 (48.6%) | 56 (46.7%) | 2 (1.9%) | 0 | 90 (36.3%) | 75 (30.2%) | 10 (4.0%) | 5 (2.0%) | 0.027 | 0.06 |
Elevated ALT | 84 (70.0%) | 71 (59.1%) | 13 (10.5%) | 0 | 160 (64.5%) | 149 (60.1%) | 11 (4.4%) | 0 | 0.30 | 0.02 |
Elevated AST | 119 (99.1%) | 79 (65.7%) | 37 (30.5%) | 3 (2.9%) | 237 (95.6%) | 185 (74.6%) | 48 (19.4%) | 4 (1.6%) | 0.13 | 0.01 |
Hyperbilirubinemia | 57 (47.6%) | 56 (46.7%) | 1 (0.95%) | 0 | 98 (39.5%) | 96 (38.7%) | 2 (0.8%) | 0 | 0.15 | 1 |
Elevated CRE | 11 (9.5%) | 11 (9.5%) | 0 | 0 | 56 (22.6%) | 56 (22.6%) | 0 | 0 | 0.002 | Â |
Hypoalbuminemia | 109 (90.5%) | 109 (90.5%) | 0 | 0 | 233 (94.0%) | 233 (94.0%) | 0 | 0 | 0.27 | Â |
Prolonged PT | 57 (47.6%) | 57 (47.6%) | 0 | 0 | 63 (25.4%) | 63 (25.4%) | 0 | 0 | <0.001 | Â |
Grades 3–4 |  |  | 56 (46.7%) |  |  | 90 (36.3%) |  | 0.056 |