Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis

Table 2 Results of the MR analyses inferring causality of psoriasis upon CAD, MI and HF risk

Trait	MR Method	MR Result in Europeans		MR Result in East Asian
Trait	MR Method	Beta (SE)	P	Beta (SE)	P
CAD	Inverse variance weighted	0.033 (0.012)	0.005	0.161 (0.075)	0.031
	MR Egger	0.029 (0.030)	0.359	− 0.074 (0.126)	0.569
	Weighted median	0.022 (0.015)	0.141	0.028 (0.098)	0.772
	Simple mode	0.017 (0.025)	0.498	0.177 (0.238)	0.472
	Weighted mode	0.019 (0.020)	0.356	0.047 (0.087)	0.602
MI	Inverse variance weighted	0.047 (0.021)	0.026	− 0.036 (0.022)	0.099
	MR Egger	0.025 (0.059)	0.674	− 0.064 (0.032)	0.069
	Weighted median	0.058 (0.027)	0.035	− 0.019 (0.032)	0.550
	Simple mode	0.066 (0.048)	0.190	− 0.048 (0.054)	0.385
	Weighted mode	0.061 (0.036)	0.113	− 0.043 (0.028)	0.144
HF	Inverse variance weighted	0.031 (0.019)	0.106	− 0.032 (0.024)	0.181
	MR Egger	0.014 (0.051)	0.789	− 0.042 (0.035)	0.255
	Weighted median	0.023 (0.024)	0.325	− 0.035 (0.031)	0.265
	Simple mode	− 0.002 (0.036)	0.960	− 0.042 (0.056)	0.467
	Weighted mode	0.022 (0.031)	0.476	− 0.039 (0.030)	0.227

MR Mendelian randomization, CAD coronary artery disease, MI myocardial infarction, HF heart failure, SE standard error

ISSN: 1741-7015