Table 3 Multivariable-adjusted HR estimates for the 10-mg/dl increase in LDL-C with or without threshold
LDL-C (mg/dl) | Primary composite outcome | Cardiovascular death | Myocardial infarction | Ischemic stroke | Hemorrhagic stroke | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI)a | −2 LLb | HR (95% CI)a | −2 LLb | HR (95% CI)a | −2 LLb | HR (95% CI)a | −2 LLb | HR (95% CI)a | −2 LLb | ||||||
≥0 (no-threshold model) | 1.05 | (1.00–1.10) | 7971.5 | 1.04 | (0.95–1.12) | 2535.0 | 1.08 | (0.97–1.20) | 1442.7 | 1.01 | (0.92–1.10) | 2183.3 | 0.89 | (0.78–1.03) | 944.2 |
≥40 | 1.05 | (1.00–1.10) | 7971.7 | 1.04 | (0.95–1.12) | 2535.0 | 1.08 | (0.97–1.20) | 1442.8 | 1.00 | (0.92–1.10) | 2183.3 | 0.88 | (0.76–1.02) | 943.9 |
≥50 | 1.05 | (1.00–1.10) | 7971.4 | 1.04 | (0.95–1.13) | 2534.9 | 1.08 | (0.97–1.20) | 1443.0 | 1.00 | (0.92–1.10) | 2183.3 | 0.87 | (0.75–1.02) | 943.7 |
≥60 | 1.06 | (1.01–1.11) | 7970.7 | 1.04 | (0.96–1.15) | 2534.6 | 1.09 | (0.97–1.22) | 1442.7 | 1.01 | (0.92–1.12) | 2183.3 | 0.86 | (0.73–1.02) | 943.7 |
≥70 | 1.07 | (1.01–1.13) | 7970.1 | 1.04 | (0.97–1.18) | 2533.8 | 1.11 | (0.98–1.25) | 1442.3 | 1.01 | (0.90–1.13) | 2183.3 | 0.87 | (0.72–1.07) | 944.8 |
≥80 | 1.07 | (1.01–1.15) | 7971.2 | 1.04 | (0.98–1.23) | 2533.5 | 1.11 | (0.96–1.29) | 1442.8 | 1.00 | (0.87–1.15) | 2183.3 | 0.92 | (0.72–1.16) | 946.2 |
≥90 | 1.07 | (0.99–1.16) | 7973.0 | 1.04 | (0.96–1.28) | 2533.9 | 1.10 | (0.92–1.33) | 1443.7 | 1.00 | (0.84–1.19) | 2183.3 | 0.96 | (0.72–1.28) | 946.7 |
≥100 | 1.06 | (0.94–1.19) | 7974.7 | 1.04 | (0.92–1.35) | 2534.6 | 1.06 | (0.81–1.38) | 1444.6 | 1.01 | (0.79–1.28) | 2183.3 | 0.95 | (0.63–1.43) | 946.7 |
≥110 | 1.07 | (0.90–1.26) | 7975.0 | 1.04 | (0.90–1.50) | 2534.6 | 1.01 | (0.66–1.55) | 1444.7 | 0.97 | (0.67–1.14) | 2183.3 | 0.88 | (0.45–1.17) | 946.6 |