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Table 1 The comparison of UMSARS items at baseline and 1- and 2-year follow-ups

From: Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

UMSARS item

Baseline (n=246)

1-year follow-up (n=246)

2-year follow-up (n=97)

p value

Post hoc tests

Median

IQR

Median

IQR

Median

IQR

Part I

 1. Speech

1

0

1

1

2

2

<0.001a

a,b,c

 2. Swallowing

0

1

1

1

1

1

<0.001a

a,b,c

 3. Handwriting

1

0

1

1

2

2

<0.001a

a,b,c

 4. Cutting food/handling utensils

1

1

2

1

2

2

<0.001a

a,b,c

 5. Dressing

1

0

1

1

2

2

<0.001a

a,b,c

 6. Hygiene

1

1

2

1

2

2

<0.001a

a,b,c

 7. Walking

1

1

2

2

3

1

<0.001a

a,b,c

 8. Falls

0

1

0

1

1

2

<0.001a

a,b,c

 9. Orthostatic symptoms

1

2

1

3

2

2

<0.001a

a,b

 10. Urinary function

2

2

3

2

3

1

<0.001a

a,b,c

 11. Sexual function

1

4

3

4

4

1

<0.001a

a,b,c

 12. Bowel function

1

2

1

2

1

2

<0.001a

a,b

Part II

 1. Facial expression

2

1

2

0

2

1

<0.001a

a,b,c

 2. Speech

1

0

1

1

2

2

<0.001a

a,b,c

 3. Ocular motor dysfunction

0

1

1

1

1

2

<0.001a

a,b

 4. Tremor at rest

0

0

0

0

0

1

0.158

 

 5. Action tremor

1

1

1

1

1

1

<0.001a

a,b,c

 6. Increased tone

1.5

2

2

1

2

1

<0.001a

a,b

 7. Rapid alternating movements

1

1

2

0

2

1

<0.001a

a,b,c

 8. Finger taps

2

1

2

1

2

1

<0.001a

a,b,c

 9. Leg agility

2

1

2

0

2

1

<0.001a

a,b,c

 10. Heel-knee-shin test

1

2

2

1

2

1

<0.001a

a,b,c

 11. Arising from chair

0

1

1

1

2

3

<0.001a

a,b,c

 12. Posture

1

1

1

1

1

1

<0.001a

a,b,c

 13. Body sway

1

1

2

2

3

2

<0.001a

a,b,c

 14. Gait

1

1

2

2

3

1

<0.001a

a,b,c

UMSARS-I

13

7

18

10

24

11

<0.001a

a,b,c

UMSARS-II

15

8

22

9

26

12

<0.001a

a,b,c

UMSARS total

28

15

40

18

48

22

<0.001a

a,b,c

  1. Post hoc tests (Bonferroni correction)
  2. Baseline vs 1-year follow-up: a, significant
  3. Baseline vs 2-year follow-up: b, significant
  4. 1- vs 2-year follow-up: c, significant
  5. UMSARS Unified Multiple System Atrophy Rating Scale, IQR interquartile range
  6. aSignificant difference