Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

Zhang, Lingyu; Hou, Yanbing; Cao, Bei; Wei, Qianqian; Ou, Ruwei; Liu, Kuncheng; Lin, Junyu; Yang, Tianmi; Xiao, Yi; Chen, Yongping; Song, Wei; Zhao, Bi; Shang, Huifang

doi:10.1186/s12916-022-02645-1

Table 2 The sensitivity to change of each item of UMSARS in patients with MSA

From: Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

UMSARS item	Baseline to 1-year follow-up (n=246)			Baseline to 2-year follow-up (n=97)			1- to 2-year follow-up (n=97)
UMSARS item	Mean annual change	SD of the change	Standardized effect	Mean annual change	SD of the change	Standardized effect	Mean annual change	SD of the change	Standardized effect
Part I
1. Speech	0.56	0.71	0.80	0.52	0.46	1.13	0.61	1.30	0.47
2. Swallowing	0.33	0.80	0.42	0.38	0.46	0.84	0.48	0.92	0.52
3. Handwriting	0.46	0.83	0.56	0.41	0.45	0.92	0.57	0.83	0.69
4. Cutting food/handling utensils	0.42	0.73	0.58	0.44	0.48	0.93	0.51	0.85	0.60
5. Dressing	0.40	0.66	0.61	0.44	0.48	0.94	0.51	0.78	0.66
6. Hygiene	0.48	0.71	0.67	0.51	0.50	1.01	0.55	0.78	0.71
7. Walking	0.57	0.78	0.73	0.63	0.44	1.41	0.77	0.75	1.03
8. Falls	0.37	1.00	0.36	0.38	0.63	0.60	0.47	1.40	0.34
9. Orthostatic symptoms	0.22	1.19	0.19	0.31	0.76	0.41	0.23	1.23	0.19
10. Urinary function	0.41	1.17	0.35	0.49	0.62	0.79	0.73	1.28	0.57
11. Sexual function	0.51	1.97	0.26	0.64	1.00	0.64	1.01	1.88	0.54
12. Bowel function	0.30	0.93	0.32	0.17	0.57	0.31	0.09	1.13	0.08
Part II
1. Facial expression	0.56	0.90	0.62	0.45	0.55	0.83	0.51	0.93	0.55
2. Speech	0.50	0.68	0.74	0.48	0.45	1.07	0.52	0.78	0.67
3. Ocular motor dysfunction	0.31	0.96	0.32	0.21	0.48	0.44	0.09	1.07	0.08
4. Tremor at rest	0.04	0.63	0.06	0.07	0.41	0.18	0.12	0.75	0.15
5. Action tremor	0.21	0.92	0.23	0.23	0.48	0.48	0.30	0.94	0.32
6. Increased tone	0.40	1.15	0.35	0.39	0.59	0.67	0.45	1.11	0.40
7. Rapid alternating movements	0.40	0.85	0.47	0.32	0.49	0.65	0.30	0.82	0.37
8. Finger taps	0.38	0.70	0.55	0.36	0.46	0.77	0.32	0.85	0.37
9. Leg agility	0.42	0.75	0.56	0.44	0.42	1.05	0.48	0.70	0.68
10. Heel-knee-shin test	0.39	0.95	0.41	0.40	0.56	0.71	0.43	0.98	0.44
11. Arising from chair	0.79	0.91	0.87	0.77	0.57	1.36	0.95	1.00	0.95
12. Posture	0.37	0.75	0.49	0.37	0.46	0.81	0.44	0.83	0.53
13. Body sway	0.62	1.00	0.61	0.61	0.64	0.95	0.66	1.11	0.59
14. Gait	0.50	0.73	0.69	0.56	0.45	1.23	0.66	0.68	0.97

UMSARS Unified Multiple System Atrophy Rating Scale, MSA multiple system atrophy, SD standard deviation

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