Category of exposureb | Hypertension PRS (tertiles)b |
|---|
Intermediatea | Higha |
|---|
| Â | Â | RERI (95% CI) | AP (95% CI) | RERI (95% CI) | AP (95% CI) |
|---|
Maternal smoking | Yes | Ref | Ref | Ref | Ref |
No | 0.34 (0.28, 0.41) | 0.35 (0.29, 0.41) | 0.21 (0.13, 0.29) | 0.16 (0.11, 0.22) |
Breastfeeding | Yes | Ref | Ref | Ref | Ref |
No | 0.32 (0.27, 0.38) | 0.32 (0.28, 0.37) | 0.13 (0.06, 0.20) | 0.09 (0.04, 0.14) |
- Adjusted for age (continuous), sex (male, female), UK Biobank assessment centre, Townsend Deprivation index (continuous), alcohol consumption (never, previous, current, missing), smoking status (never, previous, current, missing), body mass index (< 25 kg/m2, 25 to 29.9 kg/m2, ≥ 30 kg/m2, missing), physical activity (continuous), diabetes at baseline (yes/no), genotyping batch, and the first 4 genetic principal components
- Abbreviations: RERI relative excess risk due to interaction, AP attributable proportion due to interaction, CI confidence interval, PRS polygenic risk score
- aDefined by polygenic risk score: low (lowest tertiles), intermediate (second tertiles) and high (highest tertiles)
- bTo estimate RERI and AP, the maternal non-smoking category, breastfeeding category and the lowest genetic risk (low PRS) groups were the reference categories
