Fig. 4
Association between drug resistance polymorphisms and in vitro susceptibility to piperaquine measured by SYBR green I assay. Scatter plots with horizontal bars and whiskers representing median IC50s and interquartile ranges for each locus. M-mutant genotype, W- wild-type genotype, W/M- mixture of mutant and wild-type genotype in an infection. Pfcrt, Plasmodium falciparum chloroquine resistance gene; Pfmdr1, Plasmodium falciparum multidrug resistance gene 1; Pfdhps, Plasmodium falciparum dihydropteroate synthetase gene; Pfdhfr, Plasmodium falciparum dihydrofolate reductase gene; Pfpm2, Plasmodium falciparum plasmepsin 2 gene; and Pfpm3, Plasmodium falciparum plasmepsin 3 gene