Table 1 MR estimates for the association between gut microbiota and PE

Adlercreutzia

IVW

8

103.69

0.83

0.68–1.01

0.06

0.61

MR-Egger

8

0.95

0.37–2.45

0.92

1.00

Weighted median

8

0.77

0.59–1.01

0.06

0.97

Weighted mode

8

0.74

0.48–1.14

0.21

0.98

ML

8

0.82

0.67–1.00

0.04

0.50

cML-MA-BIC

8

0.82

0.68–1.00

0.05

0.39

Bifidobacterium

IVW

13

115.25

0.76

0.64–0.89

8.03E−04

0.08

MR-Egger

13

0.71

0.47–1.08

0.14

1.00

Weighted median

13

0.78

0.61–0.98

0.04

0.97

Weighted mode

13

0.75

0.54–1.03

0.10

0.98

ML

13

0.76

0.65–0.90

1.29E−03

0.07

cML-MA-BIC

13

0.75

0.64–0.89

9.24E−04

0.04

Collinsella

IVW

9

104.60

0.77

0.60–0.98

0.03

0.61

MR-Egger

9

1.50

0.60–3.75

0.42

1.00

Weighted median

9

0.71

0.51–1.01

0.05

0.97

Weighted mode

9

0.65

0.38–1.12

0.16

0.98

ML

9

0.77

0.60–0.99

0.04

0.50

cML-MA-BIC

9

0.76

0.59–0.98

0.03

0.39

Enterorhabdus

IVW

6

194.91

0.76

0.62–0.93

8.76E−03

0.23

MR-Egger

6

0.62

0.36–1.07

0.16

1.00

Weighted median

6

0.76

0.57–1.01

0.06

0.97

Weighted mode

6

0.77

0.51–1.16

0.27

0.98

ML

6

0.75

0.61–0.93

8.78E−03

0.17

cML-MA-BIC

6

0.76

0.61–0.93

9.40E−03

0.15

Eubacterium (ventriosum group)

IVW

15

90.27

0.76

0.63–0.91

2.43E−03

0.13

MR-Egger

15

0.47

0.21–1.03

0.08

1.00

Weighted median

15

0.81

0.63–1.04

0.10

1.00

Weighted mode

15

0.82

0.53–1.26

0.38

0.98

ML

15

0.76

0.63–0.91

3.05E−03

0.07

cML-MA-BIC

15

0.75

0.63–0.90

2.48E−03

0.05

Lachnospiraceae (NK4A136 group)

IVW

15

86.22

0.77

0.65–0.92

3.77E−03

0.13

MR-Egger

15

0.67

0.47–0.94

0.04

1.00

Weighted median

15

0.73

0.57–0.92

9.20E−03

0.55

Weighted mode

15

0.71

0.52–0.95

0.04

0.98

ML

15

0.77

0.66–0.91

2.05E−03

0.07

cML-MA-BIC

15

0.77

0.65–0.90

1.37E−03

0.04

Methanobrevibacter

IVW

6

137.60

0.86

0.73–1.01

0.06

0.61

MR-Egger

6

1.00

0.51–1.96

1.00

1.00

Weighted median

6

0.86

0.71–1.05

0.13

1.00

Weighted mode

6

0.88

0.69–1.12

0.35

0.98

ML

6

0.85

0.73–0.99

0.04

0.50

cML-MA-BIC

6

0.85

0.73–0.99

0.04

0.39

Tyzzerella 3

IVW

13

85.50

0.85

0.74–0.97

0.01

0.27

MR-Egger

13

0.66

0.36–1.21

0.21

1.00

Weighted median

13

0.77

0.66–0.89

6.00E−04

0.07

Weighted mode

13

0.75

0.62–0.92

0.02

0.98

ML

13

0.85

0.76–0.94

1.68E−03

0.07

cML-MA-BIC

13

0.84

0.76–0.93

1.08E−03

0.04