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Fig. 3 | BMC Medicine

Fig. 3

From: Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study

Fig. 3

MR forest plot of significant biomarkers on ER-negative breast cancer liability. Biomarkers of nominal significance in IVW MR analyses are shown in descending order of significance. The forest plot in the centre displays the odds ratio of the effect of a SD increase in genetically predicted biomarker concentration on overall breast cancer liability as a square, with error bars representing the 95% CI. In addition to the main analysis based on IVW MR, we include sensitivity analyses based on the weighted median, MR-Egger, MR-PRESSO, and MVMR accounting for known pleiotropic pathways. N. SNPs, number of SNPs; CI, confidence interval; Int. P-value, intercept P-value of MR-Egger; BMI, body mass index. An asterisk (*) indicates nominal significance. Two asterisks (**) indicate FDR-corrected significance

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