Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study

Table 1 An MR-BMA ranking of individual biomarkers according to their marginal inclusion probability with a prior probability of inclusion of 0.5 for overall breast cancer

	Exposure	Marginal inclusion probability	Model-averaged causal effect	P-value	FDR
1	Testosterone	0.979	0.079	0.001*	0.006*
2	HDL cholesterol	0.704	0.035	0.002*	0.006*
3	IGF-1	0.639	0.025	0.017*	0.032*
4	Alkaline phosphatase	0.583	−0.019	0.018*	0.032*
5	Apolipoprotein A	0.224	−0.010	0.125	0.175
6	Triglycerides	0.064	−0.001	0.868	0.987
7	Aspartate aminotransferase	0.032	0	0.987	0.987

A ranking of the seven biomarkers nominally significantly associated with overall breast cancer in IVW MR. FDR; false discovery rate. An asterisk (*) indicates nominal significance

ISSN: 1741-7015