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Fig. 2 | BMC Medicine

Fig. 2

From: A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension

Fig. 2

Manhattan and Q-Q plots for aTRH GWAS. Negative log10 transformed P-values and physical positions for SNPs in associated regions. All P values are negative log10 transformed, and both genotyped and imputed SNPs are shown (A, B). Blue line indicates suggestive association threshold, P < 1E−5; red line indicates genome-wide significance threshold, P < 5E−8 (A). Suggestive associations for aTRH: LocusZoom plots (C–F) showing the suggestive associated SNPs on chromosome 1 (C), 4 (D), 5 (E), and 15 (F) from GWAS of aTRH, respectively. Colors indicate LD between the index SNP (purple) and other SNPs based on HapMap ASN data. The rug plot indicates regional SNP density within 400kb of the suggestive SNPs in the chromosome. The recombination rate overlay (blue line, right x-axis) is based on HapMap ASN data. Gene positions and directions of transcription are annotated based on hg19 /1,000 Genomes Nov 2014 release

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