Characteristics | GWAS cohort | Validation cohort | |||||
---|---|---|---|---|---|---|---|
aTRHs | Controls | P value | aTRHs | Hypertensives | Controls | P value | |
Number of samples | 586 | 871 | Â | 65 | 96 | 100 | Â |
Age (year) | 58.4 ± 11.6 | 58.7 ± 9.7 | 0.593 | 59.3 ± 5.9 | 60.6 ± 6.7 | 59.8 ± 6.6 | 0.434 |
Sex, male (%) | 292 (49.8) | 548 (62.9) | < 0.001 | 32 (49.2) | 48 (50.0) | 51 (51.0) | 0.987 |
Body mass index (kg/m2) | 26.5 ± 3.6 | 26.2 ± 3.9 | 0.138 | 23.1 ± 1.9 | 22.6 ± 1.5 | 22.1 ± 1.4 | < 0.001 |
Waist circumference (cm) | 91.6 ± 8.7 | 83.7 ± 5.6 | < 0.001 | 90.5 ± 8.4 | 84.7 ± 6.3 | 83.2 ± 5.8 | < 0.001 |
SBP (mm Hg) | 159.8 ± 24.8 | 117.7 ± 12.1 | < 0.001 | 158.2 ± 19.1 | 144.3 ± 14.9 | 111.4 ± 7.6 | < 0.001 |
DBP (mm Hg) | 92.0 ± 15.4 | 74.3 ± 8.9 | < 0.001 | 94.9 ± 11.3 | 87.3 ± 10.5 | 69.2 ± 5.3 | < 0.001 |
Smoke (%) | 124 (21.2) | 164 (18.8) | 0.273 | 14 (21.5) | 19 (19.8) | 19 (19.0) | 0.912 |
Alcohol (%) | 91 (15.6) | 141 (16.2) | 0.736 | 11 (16.9) | 16 (16.7) | 16 (16.0) | 0.980 |
Hyperlipidemia (%) | 319 (54.4) | 0 | < 0.001 | 36 (55.4) | 0 | 0 | < 0.001 |
Coronary heart disease (%) | 171 (29.2) | 0 | < 0.001 | 19 (29.2) | 2 (2.1) | 0 | < 0.001 |
Type 2 diabetes mellitus (%) | 213 (36.3) | 0 | < 0.001 | 25 (38.5) | 2 (2.1) | 0 | < 0.001 |
Stroke (%) | 149 (25.4) | 0 | < 0.001 | 14 (21.5) | 0 | 0 | < 0.001 |
Family history of hypertension (%) | 379 (64.7) | 0 | < 0.001 | 41 (63.1) | 59 (61.5) | 0 | < 0.001 |
Antihypertensive drugs | Â | Â | Â | Â | Â | Â | Â |
Calcium channel blocker, n (%) | 530 (90.4) | 0 | < 0.001 | 59 (90.8) | 63 (65.6) | 0 | < 0.001 |
ARB or ACEi, n (%) | 372 (63.5) | 0 | < 0.001 | 43 (66.2) | 46 (47.9) | 0 | < 0.001 |
Beta-blocker, n (%) | 295 (50.3) | 0 | < 0.001 | 34 (52.3) | 33 (34.4) | 0 | < 0.001 |
Diuretics, n (%) | 511 (87.2) | 0 | < 0.001 | 57 (87.7) | 10 (10.4) | 0 | < 0.001 |