| Number of individuals |  | Comparisona | ||||
---|---|---|---|---|---|---|---|
 | Group |  |  |  |  | ||
Characteristic | Stage 1a | Stage 1b | Stage 2+ | P valuea | 1b v 1a | 2+ v 1a | 1b v 2+ |
Stage at baseline, (%) | 650 (31.1) | 1279 (61.1) | 164 (7.8) | NA | NA | NA | NA |
Mean age (y), (SD) | 17.13 (3.26) | 18.41 (3.22) | 20.30 (2.90) | <0.001 | <0.001 | <0.001 | <0.001 |
Female (%) | 383 (58.9) | 795 (62.2) | 87 (53.0) | Â | Â | Â | Â |
Social and occupational functioning | |||||||
 Mean SOFAS score, (SD)b | 66.96 (8.14) | 60.86 (8.34) | 55.91 (10.29) | <0.001 | <0.001 | <0.001 | <0.001 |
 NEET (%) | 49 (7.5) | 227 (17.7) | 58 (35.4) | <0.001 | <0.001 | <0.001 | <0.001 |
Clinical presentation (%) | |||||||
 Manic-like experiences | 22 (3.4) | 229 (17.9) | 70 (42.7) | <0.001 | <0.001 | <0.001 | <0.001 |
 Psychotic-like experiences | 42 (6.5) | 256 (20.0) | 86 (52.4) | <0.001 | <0.001 | <0.001 | <0.001 |
 Circadian disturbance | 43 (6.6) | 208 (16.3) | 59 (36.0) | <0.001 | <0.001 | <0.001 | <0.001 |
 Neurodevelopmental - ASD | 25 (3.8) | 58 (4.5) | 7 (4.3) |  |  |  |  |
 Neurodevelopmental - ADHD | 57 (8.8) | 111 (8.7) | 8 (4.9) |  |  |  |  |
 Neurodevelopmental - other | 22 (3.4) | 25 (2.0) | 1 (0.6) |  |  |  |  |
Personal history of mental illness (%) | |||||||
 Any childhood disorder | 70 (10.8) | 202 (15.8) | 24 (14.6) |  |  |  |  |
 Any family history | 262 (40.2) | 656 (51.3) | 89 (54.3) | <0.001 | <0.001 |  |  |
Physical health comorbidities (%) | |||||||
 Any major physical illness | 96 (14.8) | 193 (15.1) | 37 (22.6) |  |  |  |  |
Alcohol and/or substance misuse (%) | |||||||
 Any alcohol and/or substance misuse | 17 (2.6) | 128 (10.0) | 27 (16.5) | <0.001 | <0.001 | <0.001 |  |
Treatment utilisation (%) | |||||||
 Any hospitalisation | 5 (0.8) | 162 (12.7) | 115 (70.1) | <0.001 | <0.001 | <0.001 | <0.001 |
 Any psychiatric medication | 111 (17.1) | 704 (55.0) | 149 (90.0) | <0.001 | <0.001 | <0.001 | <0.001 |
Self-harm and suicidal thoughts and behaviours (%) | |||||||
 Self-harm | 146 (22.5) | 650 (50.8) | 73 (44.5) | <0.001 | <0.001 | <0.001 |  |
 Suicidal ideation | 194 (29.8) | 733 (57.3) | 101 (61.6) | <0.001 | <0.001 | <0.001 |  |
 Suicide attempt | 17 (2.6) | 231 (18.1) | 54 (32.9) | <0.001 | <0.001 | <0.001 | <0.001 |