Fig. 4
From: Tumor PKCδ instigates immune exclusion in EGFR-mutated non–small cell lung cancer
PKCδ enhanced PD-L1 expression and induced immune escape. A PKCδ inhibitor rottlerin significantly suppressed the expression of PD-L1 in EGFR-mutated H1975, while PKCδ activator PEP-005 increased PD-L1 in EGFR-WT A549 and H460 cells. B FACS results showed that PKCδ knockout in H1975 decreased cell surface PD-L1 level, whereas PEP-005 upregulated its expression in A549 and H460. C, D High phosphorylation of PKCδ was detected in 51.0% of 100 lung tumor specimens, 34 cases out of 51 (66.7%) showed high PD-L1 expression (−/+ represents that that both the expression of p-PKCδ and PD-L1 are low or even non-expression, while +++/+++ means that both the expression of p-PKCδ and PD-L1 are high)