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Table 4 Association between the use of PPI and maternal and neonatal outcomes presented as the odds ratio of having the outcome compared to non-users

From: Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events

PPI use

Pre-eclampsia

GDM

Preterm

AS5min < 7

SGA

LGA

Number of prescriptions

      

2

1.21 (1.09–1.36)

1.24 (1.07–1.44)

1.11 (1.01–1.23)

1.00 (0.83–1.21)

1.31 (1.14–1.49)

0.81 (0.71–0.92)

3

1.30 (1.11–1.52)

1.35 (1.10–1.67)

1.56 (1.37–1.78)

1.07 (0.81–1.40)

1.19 (0.97–1.47)

0.85 (0.71–1.03)

 ≥ 4

1.05 (0.89–1.24)

1.32 (1.10–1.59)

1.19 (1.03–1.36)

1.19 (0.93–1.53)

1.28 (1.05–1.56)

0.87 (0.74–1.02)

Number of weeks

      

0–12

1.34 (1.16–1.54)

1.38 (1.14–1.68)

1.06 (0.93–1.21)

1.02 (0.79–1.32)

1.14 (0.94–1.37)

0.82 (0.69–0.97)

12–20

1.19 (1.00–1.42)

1.41 (1.14–1.75)

1.29 (1.12–1.49)

1.01 (0.75–1.37)

1.29 (1.05–1.60)

0.92 (0.77–1.11)

20–36

1.23 (1.05–1.43)

1.14 (0.92–1.40)

1.16 (1.01–1.34)

0.96 (0.73–1.28)

1.45 (1.20–1.74)

0.79 (0.66–0.95)

 > 36

1.01 (0.86–1.18)

1.26 (1.04–1.52)

1.45 (1.27–1.65)

1.24 (0.98–1.57)

1.25 (1.03–1.52)

0.83 (0.70–0.98)

  1. Abbreviations: AS5min, Apgar score 5 min after birth; DDD, defined daily doses; GDM, gestational diabetes; LGA, large for gestational age; PPI, proton pump inhibitor; SGA, small for gestational age