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Fig. 7 | BMC Medicine

Fig. 7

From: A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway

Fig. 7

Inhibition of the ROS/PI3K/Akt/mTOR signaling pathway by 450-nm laser/DVDMS-mediated PDT. A KEGG pathway enrichment analysis of differentially expressed transcripts in HGC27 cells. B Western blotting analysis of the expression levels of pathway-related proteins after the treatment of 24 h. C Quantitative analysis of B (n = 3, mean ± SD). D Western blotting analysis of the expression levels of autophagy- and pathway-related proteins after adding inhibitor LY294002 and activator 740 Y-P for 24 h. E Quantitative analysis of D (n = 3, mean ± SD). F Western blotting analysis of the expression levels of autophagy- and pathway-related proteins after adding ROS scavenger NAC (incubation 2 h). G Quantitative analysis of F (n = 3, mean ± SD). H TEM images of the autophagic vacuoles (indicated by the red arrow) after adding NAC. *p < 0.05, **p < 0.01, and ***p < 0.001

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BMC Medicine

ISSN: 1741-7015

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