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Fig. 4 | BMC Medicine

Fig. 4

From: Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

Fig. 4

Pair-wise effect size comparison between different cohorts. A Comparison of effect sizes for the 202 heterogeneous associations between the LLD cohort and the 300OB cohorts. X-axis is the estimated effect size in the LLD cohort. Y-axis is the estimated effect size in the 300OB cohort. Each dot represents a heterogeneous association, colored by association with the different BCAAs: light blue for isoleucine, orange for leucine, and dark blue for valine. B Comparison of effect sizes for the 202 heterogeneous associations between age and BMI-matched 185 LLD individuals and the 300OB cohorts. X-axis represents the estimated effect size in the matched LLD obesity individuals. Y-axis represents the estimated effect size in the 300OB cohort. Each dot represents a heterogeneous association, colored by association with different BCAAs: light blue for isoleucine, orange for leucine, and dark blue for valine. C Effect size comparison between the whole LLD cohort and the subset of LLD individuals with age and BMI matched to the 300OB cohort. X-axis is the estimated effect size (beta value) in the whole LLD cohort. Y-axis is the estimated effect size (beta value) with LLD obesity individuals. Each dot represents an association between a BCAA and a CMD parameter. Dots are colored light blue for isoleucine, dark blue for valine, and orange for leucine and fitted with separate lines for the different BCAAs. The consistency between two estimations was assessed using Pearson correlation for all BCAAs together or for the different type of BCAAs separately

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