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Fig. 1 | BMC Medicine

Fig. 1

From: Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

Fig. 1

PAE-associated differential DNAm in the placenta. a Volcano plot showing the distribution of associations between placental CpG sites and PAE. Horizontal line marks FDR 0.05 and vertical line marks effect size ± 0.05. b Venn diagram showing the number of PAE-associated DMPs, which are in common between all PAE placentas and the early PAE subgroup. c Genomic location of PAE- and early PAE-associated DMPs in relation to gene and CpG island in the placenta. DMPs were divided to hypo- and hypermethylated subgroups, which were further grouped according to the genomic location based on UCSC database. If the location information was missing, DMP was marked as “unknown.” In the case of multiple location entries, group “others” was used. d Effects of PAE on global placental DNAm level predicted by Alu, LINE1, and LTR repetitive regions in all PAE placentas and in the early PAE subgroup. *P < 0.05, two-tailed Student’s t test. Control n = 66, PAE n = 69, and early PAE n = 27. Abbreviations TSS1500: 1500 bp upstream of transcription start site, TSS200: 200 bp upstream of TSS, UTR: untranslated region, N_shelf: north shelf, N_shore: north shore, S_shore: south shore, S_shelf: south shelf

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