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Fig. 3 | BMC Medicine

Fig. 3

From: Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

Fig. 3

DNAm levels of potential PAE biomarkers DPPA4, FOXP2, and TACR3. a Box plots showing the normalized DNAm levels of DMPs and their locations in relation to gene in DPPA4, FOXP2, and TACR3 in control, PAE, and early PAE placentas. Four DMPs with the largest effect sizes (mean Δβ) based on linear model of each candidate gene are presented. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, two-tailed Student’s t test. b Box plots showing sex-specific normalized DNAm levels of DMPs with the largest effect sizes. *P < 0.05, **P < 0.01, two-tailed Student’s t test. c DNAm levels of DPPA4 DMP (cg14836960) and TACR3 DMP (cg16461251) in selected placental samples analyzed by microarrays and EpiTYPER as well as the same CpGs in WBCs and in BECs analyzed by EpiTYPER. Blue dots in DPPA4 indicate DMP of each PAE placenta, which have the lowest DNAm levels in microarrays. **P < 0.01, ****P < 0.0001, Mann-Whitney U

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BMC Medicine

ISSN: 1741-7015

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