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Fig. 6 | BMC Medicine

Fig. 6

From: Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

Fig. 6

Effects of alcohol exposure on DPPA2 and DPPA4 in hESCs and differentiating cells. aDPPA2 and DPPA4 gene expressions in control (n = 12) and alcohol-exposed (n = 13) hESCs. bDPPA2 and DPPA4 DNAm profiles in control and alcohol-exposed hESCs (n = 8/condition). cDPPA2 and DPPA4 histone modifications in control and alcohol-exposed hESCs (n = 4/condition). Histone modification enrichments were normalized to the total histone H3. dDPPA2 and DPPA4 DNAm profiles in control and alcohol-exposed differentiated endo-, meso-, and ectodermal cells (n = 4/condition, respectively). eDPPA2 and DPPA4 DNAm profiles in control (n = 66) and PAE (n = 69) placentas. Data presented as mean ±SD. *P < 0.05, Mann-Whitney U and ****P < 0.0001, FDR-corrected P-value

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BMC Medicine

ISSN: 1741-7015

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