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Table 1 Methylation sites in placenta associated with level of social support during pregnancy (n = 301)

From: Prenatal social support in low-risk pregnancy shapes placental epigenome

CpG

Gene

Chr: position

Relation to Gene

Relation to Island

Mean methylation

Beta (SD)

Methylation LogFC ± S.E.

P-valuea

PFDR

cg14806252

HAUS3

4:2244001

TSS200

Island

0.008 (0.005)

0.22 ± 0.04

4.6 × 10−8

0.019

cg01924481

SBF1

22:50898563

Body

Island

0.865 (0.020)

0.02 ± 0.003

1.3 × 10−7

0.021

cg11364468

VGF

7:100807505

Body

Island

0.011 (0.006)

0.11 ± 0.02

1.5 × 10−7

0.021

cg00549575

EIF3F

11:8008752

TSS200

N_Shore

0.040 (0.016)

0.08 ± 0.02

3.3 × 10−7

0.030

cg19499754

FAM210B

20:54919155

 

Island

0.029 (0.013)

0.11 ± 0.02

3.7 × 10−7

0.030

cg16763895

ILVBL

19:15235973

5'UTR

Island

0.030 (0.010)

0.07 ± 0.01

6.0 × 10−7

0.041

cg02672368

ARHGEF7

13:111805930

Body; TSS200

Island

0.017 (0.008)

0.13 ± 0.03

8.4 × 10−7

0.049

  1. aAdjusted for maternal age, race/ethnicity, pre-pregnancy BMI, education, job status, gestational age, parity, fetal sex, perceived stress, methylation principal components, genotype principal components, and surrogate variable
  2. CpG cytosine-(phosphate)-guanine site, FDR false discovery rate, LogFC logarithm of fold change, S.E standard error, SD standard deviation