Variables | Unexposed (n = 5,771,095), N (%) | Exposure type | |
---|---|---|---|
Any loss in childhood (n = 248,970), N (%) | Any loss in adulthood (n = 374,910), N (%) | ||
Country | |||
Denmark | 2,533,112 (43.9) | 120,338 (48.3) | 196,561 (52.4) |
Sweden | 3,237,983 (56.1) | 128,632 (51.7) | 178,349 (47.6) |
Sex | |||
Men | 2,955,678 (51.2) | 127,468 (51.2) | 193,714 (51.7) |
Women | 2,811,917 (48.7) | 121,353 (48.7) | 181,192 (48.3) |
Missing | 3500 (0.1) | 149 (0.1) | 4 (< 0.1) |
Gestational age of offspring (weeks) | |||
< 32 | 43,800 (0.8) | 3657 (1.5) | 1642 (0.4) |
32–36 | 272,138 (4.7) | 14,202 (5.7) | 14,597 (3.9) |
> 36 | 5,152,821 (89.3) | 202,153 (81.2) | 258,182 (68.9) |
Missing | 302,336 (5.2) | 28,958 (11.6) | 100,489 (26.8) |
Parents’ country of birtha | |||
Denmark or Sweden | 4,941,683 (85.6) | 202,582 (81.4) | 334,062 (89.1) |
Other countries | 829,412 (14.4) | 46,388 (18.6) | 40,848 (10.9) |
Parents’ highest educational level (years)b | |||
0–9 | 342,608 (5.9) | 42,217 (17.0) | 65,840 (17.6) |
10–14 | 3,144,996 (54.5) | 145,202 (58.3) | 224,346 (59.8) |
≥ 15 | 2,262,151 (39.2) | 60,435 (24.3) | 84,192 (22.5) |
Missing | 21,340 (0.4) | 1116 (0.4) | 432 (0.1) |
Maternal income at offspring’s birthc | |||
Low tertile | 1,812,644 (31.4) | 89,081 (35.8) | 121,605 (32.4) |
Middle tertile | 1,945,845 (33.7) | 73,090 (29.4) | 106,877 (28.5) |
High tertile | 1,917,486 (33.2) | 76,422 (30.7) | 105,445 (28.1) |
Missing | 95,120 (1.6) | 10,377 (4.2) | 40,983 (10.9) |
Paternal income | |||
Low tertile | 1,857,048 (32.2) | 102,063 (41.0) | 120,052 (32.0) |
Middle tertile | 1,902,257 (33.0) | 69,308 (27.8) | 106,460 (28.4) |
High tertile | 1,903,458 (33.0) | 66,366 (26.7) | 107,096 (28.6) |
Missing | 108,332 (1.9) | 11,233 (4.5) | 41,302 (11.0) |
Maternal age at offspring’s birth (years) | |||
< 20 | 131,853 (2.3) | 9215 (3.7) | 15,162 (4.0) |
20–24 | 1,059,666 (18.4) | 49,745 (20.0) | 87,263 (23.3) |
25–29 | 2,061,402 (35.7) | 76,435 (30.7) | 129,050 (34.4) |
30–34 | 1,706,237 (29.6) | 66,883 (26.9) | 93,727 (25.0) |
> 34 | 811,937 (14.1) | 46,692 (18.8) | 49,708 (13.3) |
Maternal smoking in early pregnancy | |||
No | 3,373,378 (58.5) | 77,711 (31.2) | 33,144 (8.8) |
Yes | 682,436 (11.8) | 43,983 (17.7) | 23,252 (6.2) |
Missing | 1,715,281 (29.7) | 127,276 (51.1) | 318,514 (85.0) |
Maternal BMI in early pregnancy (kg/m2) | |||
< 30 | 2,567,603 (44.5) | 57,396 (23.1) | 29,859 (8.0) |
≥ 30 | 292,351 (5.1) | 6458 (2.6) | 1481 (0.4) |
Missing | 2,911,141 (50.4) | 185,116 (74.4) | 343,570 (91.6) |
Maternal hypertension before offspring’s birth | |||
No | 5,321,343 (92.2) | 218,775 (87.9) | 289,602 (77.2) |
Yes | 266,451 (4.6) | 10,703 (4.3) | 9741 (2.6) |
Missing | 183,301 (3.2) | 19,492 (7.8) | 75,567 (20.2) |
Maternal diabetes before offspring’s birth | |||
No | 5,513,046 (95.5) | 227,012 (91.2) | 297,769 (79.4) |
Yes | 74,748 (1.3) | 2466 (1.0) | 1574 (0.4) |
Missing | 183,301 (3.2) | 19,492 (7.8) | 75,567 (20.2) |
Parents’ CVD before offspring’s birth | |||
No | 5,276,302 (91.4) | 215,185 (86.4) | 290,662 (77.5) |
Yes | 311,492 (5.4) | 14,293 (5.7) | 8681 (2.3) |
Missing | 183,301 (3.2) | 19,492 (7.8) | 75,567 (20.2) |
Parents’ psychiatric disorders before offspring’s birth | |||
No | 5,236,886 (90.9) | 220,964 (88.8) | 360,603 (96.2) |
Yes | 524,209 (9.1) | 28,006 (11.2) | 14,307 (3.8) |
Family history of CVD before offspring’s birthd | |||
No | 2,273,064 (39.4) | 62,183 (25.0) | 95,224 (25.4) |
Yes | 2,460,022 (42.6) | 95,199 (38.2) | 92,884 (24.8) |
Missing | 1,038,009 (18.0) | 91,588 (36.8) | 186,802 (49.8) |
Family history of psychiatric disorders before offspring’s birthd | |||
No | 3,306,066 (57.3) | 96,215 (38.6) | 135,857 (36.2) |
Yes | 1,296,122 (22.5) | 50,782 (20.4) | 39,885 (10.6) |
Missing | 1,168,907 (20.3) | 101,973 (41.0) | 199,168 (53.1) |