Table 1 Characteristics of the cohorts and offspring included in the analysisa
Cohort name | ALSPAC | BiB | YFS | NFBC1986 | NFBC1966 | HBCS | BIS | CheckPoint |
|---|---|---|---|---|---|---|---|---|
Cohort country | UK | UK | Finland | Finland | Finland | Finland | Australia | Australia |
Offspring birth years | 1990–1992 | 2007–2011 | 1962–1977 | 1985–1986 | 1966 | 1934–1944 | 2010–2013 | 2003–2004 |
Mean age(s) (in years) at assessment of NMR-derived metabolic traits | 7.5 years, 15.4 years, 17.8 years, 24.5 years | 0 (cord blood), 1.6 years | 22.0 years | 16.0 years | 31.2 years, 46.6 years | 67.8 years | 0 (cord blood), 1.1 years, 4.2 years | 12.0 years |
Sex [No. (%)] | ||||||||
 Male | 3216 (49.6) | 1290 (51.6) | 204 (40.0%) | 2305 (50.0) | 2400 (47.9) | 466 (44.0%) | 374 (51.5) | 429 (47.8) |
 Female | 3263 (50.4) | 1209 (48.4) | 305 (60.0%) | 2309 (50.0) | 2607 (52.1) | 593 (56.0%) | 352 (48.5) | 469 (52.2) |
Pre-eclampsia [No. (%)] | ||||||||
 No | 6335 (98.1) | 2328 (97.2) | 499 (98.0%) | 3596 (97.5) | 2883 (96.3) | - | 701 (97.0) | - |
 Yes | 120 (1.9) | 66 (2.8) | 10 (2.0%) | 91 (2.5) | 110 (3.7) | - | 22 (3.0) | - |
Gestational hypertension [No. (%)] | ||||||||
 No | 5433 (85.8) | 2215 (92.5) | 492 (97.0%) | 3596 (96.4) | 2883 (86.9) | - | 713 (98.2) | 843 (94.2) |
 Yes | 902 (14.2) | 179 (7.5) | 17 (3.0%) | 134 (3.6) | 406 (13.1) | - | 13 (1.8) | 52 (5.8) |
Gestational diabetes [No. (%)] | ||||||||
 No | 6424 (99.5) | 1091 (84.7) | 468 (92%) | - | - | - | 582 (95.7) | 846 (95.1) |
 Yes | 31 (0.5) | 197 (15.3) | 41 (8%) | - | - | - | 26 (4.3) | 44 (4.9) |
Preterm birth [No. (%)] | ||||||||
 No | 6156 (95.0) | 2342 (93.7) | 460 (90,0%) | 4381 (95.0) | 4775 (95.4) | 1000 (94.4) | 682 (93.9) | 800 (89.6) |
 Yes | 323 (5.0) | 157 (6.3) | 49 (10.0%) | 230 (5.0) | 225 (4.6) | 59 (5.6) | 44 (6.0) | 93 (10.4) |
Small for gestational age [No. (%)] | ||||||||
 No (appropriate size for age) | 5446 (94.4) | 2140 (90.8) | - | 3842 (96.5) | 3928 (94.5) | - | 631 (98.3) | 764 (95.3) |
 Yes | 323 (5.6) | 216 (9.2) | - | 138 (3.5) | 227 (5.6) | - | 11 (1.7) | 38 (4.7) |
Large for gestational age [No. (%)] | ||||||||
 No (appropriate size for age) | 5446 (89.9) | 2140 (93.8) | - | 3842 (86.1) | 3928 (89.6) | - | 631 (88.3) | 764 (89.6) |
 Yes | 610 (10.1) | 142 (6.2) | - | 621 (13.9) | 454 (10.4) | - | 84 (11.8) | 89 (10.4) |