- The addition of peripapillary RNFL thickness to the Framingham Risk Score results in an additive net reclassification improvement (NRI) of 21.8% (p = 0.026) and an absolute NRI of 2.0%. The green cells represent patients correctly reclassified. The yellow cells represent risk stratification that is unchanged in the novel model. The red cells represent patients incorrectly reclassified. RNFL retinal nerve fiber layer, CVD cardiovascular disease