Table 1 Baseline characteristics of the study participants
Characteristics | Total | CumAIP < − 0.0701 and CumCRP < 1 mg/L | CumAIP < − 0.0701 and 1 ≤ CumCRP < 3 mg/L | CumAIP < − 0.0701 and CumCRP ≥ 3 mg/L | CumAIP ≥ − 0.0701 and CumCRP < 1 mg/L | CumAIP ≥ − 0.0701 and 1 ≤ CumCRP < 3 mg/L | CumAIP ≥ − 0.0701 and CumCRP ≥ 3 mg/L | P value |
|---|---|---|---|---|---|---|---|---|
Cumulative characteristics of lipid profiles and hsCRP | ||||||||
 CumHDL-C, median (IQR), mmol/L | 1.5 (1.3, 1.8) | 1.7 (1.5, 1.9) | 1.7 (1.5, 1.9) | 1.7 (1.5, 1.9) | 1.4 (1.2, 1.6) | 1.4 (1.2, 1.6) | 1.4 (1.2, 1.6) | < 0.0001 |
 CumLDL-C, mean (SD), mmol/L | 2.6 (0.7) | 2.5 (0.7) | 2.6 (0.7) | 2.5 (0.9) | 2.6 (0.6) | 2.7 (0.7) | 2.6 (0.8) | < 0.0001 |
 CumTG, median (IQR), mmol/L | 1.3 (1.0, 1.9) | 0.9 (0.7, 1.1) | 1.0 (0.8, 1.2) | 1.0 (0.8, 1.2) | 1.8 (1.4, 2.4) | 1.9 (1.5, 2.6) | 2.0 (1.5, 2.7) | < 0.0001 |
 CumTC, mean (SD), mmol/L | 5.1 (1.0) | 4.9 (0.9) | 5.1 (1.0) | 5.1 (1.0) | 5.1 (1.0) | 5.2 (1.0) | 5.4 (1.1) | < 0.0001 |
 CumAIP, mean (SD) | − 0.06 (0.27) | − 0.24 (0.17) | − 0.21 (0.15) | − 0.22 (0.16) | 0.18 (0.17) | 0.20 (0.18) | 0.22 (0.19) | < 0.0001 |
 CumCRP, median (IQR), mg/L | 1.5 (0.8, 3.0) | 0.6 (0.4, 0.8) | 1.7 (1.3, 2.2) | 5.1 (3.8, 7.6) | 0.7 (0.5, 0.8) | 1.7 (1.3, 2.2) | 4.9 (3.8, 7.1) | < 0.0001 |
Baseline characteristics | ||||||||
 Age, mean (SD), years | 52.1 (11.8) | 50.2 (11.7) | 52.4 (12.0) | 56.0 (12.2) | 50.0 (11.0) | 51.5 (11.5) | 54.4 (11.7) | < 0.0001 |
 Male (%) | 32,618 (75.2) | 5353 (66.2) | 6173 (71.9) | 3620 (72.3) | 4969 (83.9) | 8113 (81.4) | 4390 (75.8) | < 0.0001 |
 AIP, mean (SD) | − 0.06 (0.31) | − 0.24 (0.23) | − 0.20 (0.22) | − 0.18 (0.22) | 0.17 (0.26) | 0.20 (0.26) | 0.22 (0.26) | < 0.0001 |
 BMI, mean (SD), kg/m2 | 25.0 (3.3) | 23.3 (2.9) | 24.3 (3.2) | 24.8 (3.4) | 25.0 (2.9) | 26.0 (3.1) | 26.7 (3.4) | < 0.0001 |
 SBP, mean (SD), mmHg | 129.5 (18.6) | 124.1 (17.9) | 128.5 (18.8) | 131.0 (19.5) | 128.4 (17.4) | 131.8 (18.0) | 134.1 (18.8) | < 0.0001 |
 DBP, median (IQR), mmHg | 80.7 (79.3, 90.0) | 80.0 (72.0, 88.3) | 80.0 (78.0, 90.0) | 80.0 (79.3, 90.0) | 82.0 (80.0, 90.0) | 84.7 (80.0, 90.0) | 85.0 (80.0, 90.7) | < 0.0001 |
 FBG, mean (SD), mmol/L | 5.2 (0.6) | 5.2 (0.5) | 5.2 (0.6) | 5.2 (0.6) | 5.3 (0.6) | 5.3 (0.6) | 5.3 (0.6) | < 0.0001 |
 HDL-C, median (IQR), mmol/L | 1.5 (1.3, 1.8) | 1.7 (1.4, 2.1) | 1.7 (1.4, 2.0) | 1.6 (1.4, 1.9) | 1.4 (1.2, 1.6) | 1.4 (1.2, 1.6) | 1.3 (1.1, 1.6) | < 0.0001 |
 LDL-C, mean (SD), mmol/L | 2.6 (0.8) | 2.5 (0.7) | 2.7 (0.7) | 2.2 (0.9) | 2.6 (0.7) | 2.8 (0.7) | 2.5 (1.0) | < 0.0001 |
 TC, mean (SD), mmol/L | 5.0 (1.0) | 4.9 (1.0) | 4.9 (0.9) | 4.9 (0.9) | 5.0 (0.9) | 5.1 (1.0) | 5.1 (1.1) | < 0.0001 |
 TG, median (IQR), mmol/L | 1.3 (0.9–1.8) | 0.9 (0.7, 1.2) | 1.0 (0.7–1.2) | 1.0 (0.7–1.3) | 1.6 (1.2–2.3) | 1.8 (1.3–2.5) | 1.8 (1.4–2.6) | < 0.0001 |
 eGFR, median (IQR), mL/min/1.73 m2 | 82.1 (59.7, 97.0) | 89.4 (66.3, 102.0) | 85.4 (60.4, 98.3) | 78.1 (58.7, 93.1) | 74.3 (57.5, 96.1) | 78.9 (58.4, 95.8) | 73.7 (58.0, 93.0) | < 0.0001 |
 HsCRP, median (IQR), mg/L | 1.0 (0.5, 2.4) | 0.5 (0.3, 0.9) | 1.3 (0.7, 2.3) | 3.1 (1.1, 6.4) | 0.5 (0.1, 0.9) | 1.2 (0.6, 2.2) | 3.1 (1.2, 6.1) | < 0.0001 |
 Current drinker (%) | 15,201 (35.1) | 2761 (34.1) | 2822 (32.9) | 1324 (26.4) | 2534 (42.8) | 3925 (39.4) | 1835 (31.7) | < 0.0001 |
 Current smokers (%) | 14,717 (33.9) | 2444 (30.2) | 2735 (31.9) | 1423 (28.4) | 2296 (38.8) | 3831 (38.4) | 1988 (34.3) | < 0.0001 |
 Family history of diabetes | 2300 (5.3) | 448 (5.5) | 414 (4.8) | 215 (4.3) | 334 (5.6) | 570 (5.7) | 319 (5.5) | 0.0011 |
 Education (%) |  |  |  |  |  |  |  | < 0.0001 |
  Less than senior high school | 32,892 (75.9) | 5745 (71.0) | 6496 (75.7) | 4060 (81.1) | 4419 (74.6) | 7517 (75.4) | 4655 (80.4) |  |
  Senior high school and above | 10,468 (24.1) | 2341 (29.0) | 2089 (24.3) | 949 (18.9) | 1506 (25.4) | 2449 (24.6) | 1134 (19.6) |  |
 Physical activities (%) |  |  |  |  |  |  |  | < 0.0001 |
 Low | 14,568 (33.6) | 2971 (36.7) | 2711 (31.6) | 1671 (33.4) | 2048 (34.6) | 3224 (32.3) | 1943 (33.6) |  |
 Moderate | 22,710 (52.4) | 3943 (48.8) | 4538 (52.9) | 2745 (54.8) | 3057 (51.6) | 5327 (53.5) | 3100 (53.5) |  |
 High | 6082 (14.0) | 1172 (14.5) | 1336 (15.6) | 593 (11.8) | 820 (13.8) | 1415 (14.2) | 746 (12.9) |  |
 Hypertension (%) | 20,881 (48.2) | 2762 (34.2) | 3751 (43.7) | 2533 (50.6) | 2825 (47.7) | 5495 (55.1) | 3515 (60.7) | < 0.0001 |
 Dyslipidemia (%) | 11,821 (27.3) | 960 (11.9) | 1046 (12.2) | 695 (13.9) | 2201 (37.1) | 4223 (42.4) | 2696 (46.6) | < 0.0001 |
 Moderate and severe fatty liver (%) | 5785 (13.3%) | 278 (3.4%) | 598 (6.9%) | 475 (9.5%) | 754 (12.7%) | 2169 (21.8%) | 1611 (26.1%) | < 0.0001 |
 Anti-hypertensives (%) | 2305 (5.3) | 218 (2.7) | 360 (4.2) | 277 (5.5) | 308 (5.2) | 640 (6.4) | 502 (8.7) | < 0.0001 |
 Statins | 252 (0.6) | 26 (0.3) | 31 (0.4) | 20 (0.4) | 38 (0.6) | 69 (0.7) | 68 (1.2) | < 0.0001 |
 Fibrate | 95 (0.2) | 1 (0.0) | 7 (0.1) | 6 (0.1) | 18 (0.3) | 30 (0.3) | 33 (0.6) | < 0.0001 |