| CumAIP, HRs (95% CIs) | Per SDa | P for trend | |||
---|---|---|---|---|---|---|
Quartile1 | Quartile 2 | Quartile 3 | Quartile 4 | |||
Entire cohort | ||||||
 Event/total | 684/10, 840 | 1023/10, 840 | 1395/10, 840 | 2016/10, 840 |  |  |
 Incident rate | 8.6 | 13.37 | 18.6 | 27.32 |  |  |
 Model 1 | Reference | 1.37 (1.24, 1.51) | 1.76 (1.60, 1.93) | 2.40 (2.20, 2.63) | 1.36 (1.32, 1.39) | < 0.0001 |
 Model 2 | Reference | 1.26 (1.14, 1.39) | 1.55 (1.41, 1.70) | 2.03 (1.85, 2.22) | 1.28 (1.24, 1.31) | < 0.0001 |
 Model 3 | Reference | 1.23 (1.11, 1.35) | 1.44 (1.31, 1.58) | 1.75 (1.60, 1.92) | 1.20 (1.17, 1.24) | < 0.0001 |
CumCRP < 1 mg/L | ||||||
 Event/total | 191/4462 | 238/3624 | 321/3287 | 388/2638 |  |  |
 Incident rate | 5.76 | 9.2 | 13.88 | 21.35 |  |  |
 Model 1 | Reference | 1.38 (1.14, 1.67) | 1.92 (1.59, 2.30) | 2.78 (2.31, 3.33) | 1.47 (1.39, 1.56) | < 0.0001 |
 Model 2 | Reference | 1.27 (1.05, 1.54) | 1.59 (1.32, 1.91) | 2.28 (1.90, 2.75) | 1.36 (1, 29, 1.45) | < 0.0001 |
 Model 3 | Reference | 1.24 (1.02, 1.50) | 1.48 (1.23, 1.79) | 1.99 (1.65, 2.40) | 1.28 (1.20, 1.36) | < 0.0001 |
1 ≤ CumCRP < 3 mg/L | ||||||
 Event/total | 304/3952 | 485/4633 | 658/4932 | 954/5034 |  |  |
 Incident rate | 10.55 | 14.83 | 19.31 | 27.85 |  |  |
 Model 1 | Reference | 1.26 (1.10, 1.46) | 1.55 (1.35, 1.77) | 2.13 (1.86, 2.44) | 1.31 (1.26, 1.37) | < 0.0001 |
 Model 2 | Reference | 1.15 (0.99, 1.32) | 1.37 (1.20, 1.58) | 1.81 (1.58, 2.07) | 1.25 (1.20, 2.30) | < 0.0001 |
 Model 3 | Reference | 1.14 (0.98, 1.31) | 1.31 (1.14, 1.50) | 1.62 (1.41, 1.85) | 1.19 (1.14, 1.24) | < 0.0001 |
CumCRP ≥ 3 mg/L | ||||||
 Event/total | 189/2426 | 300/2583 | 416/2621 | 674/3168 |  |  |
 Incident rate | 10.79 | 16.74 | 23.38 | 31.55 |  |  |
 Model 1 | Reference | 1.41 (1.18, 1.70) | 1.84 (1.54, 2.18) | 2.31 (1.96, 2.73) | 1.30 (1.24, 1.36) | < 0.0001 |
 Model 2 | Reference | 1.34 (1.12, 1.61) | 1.68 (1.41, 2.01) | 2.00 (1.69, 2.37) | 1.23 (1.17, 1.29) | < 0.0001 |
 Model 3 | Reference | 1.30 (1.08, 1.56) | 1.58 (1.32, 1.88) | 1.73 (1.46, 2.06) | 1.16 (1.10, 1.22) | < 0.0001 |
P for INTm: CumAIP quartile × CumCRP thresholds (1, 3 mg/L) = 0.0308; CumAIP quartiles × logCumCRP = 0.0286 |