Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study

Table 3 Full model site comparison: maternal pre-pregnancy BMI and offspring hypothalamic (HTH) mean diffusivity (MD)

Maternal pBMI and offspring hypothalamic (HTH) mean diffusivity (MD): full model
	Site 1 (n = 152)			Site 2 (n = 79)
Independent variable	\(\hat{\boldsymbol{\beta}}\)	R²_partial	p	\(\hat{\boldsymbol{\beta}}\)	R²_partial	p
Maternal pre-preg. BMI	0.15	3.5%	0.0289	0.26	9.4%	0.009
Gestational age at birth	0.21	3.2%	0.0344	0.17	2.2%	0.214
Postnatal age at scan	0.45	13.5%	< 0.001	0.21	2.6%	0.181
Infant sex (male)	0.13	2.5%	0.0608	0.13	0.7%	0.479
White matter MD	0.58	28.1%	< 0.001	0.64	18.8%	< 0.001
QC (framewise displacement)	na^a	na^a	na^a	0.16	4.3%	0.085
Maternal education	0.02	1.7%	0.6771	0.27	8.7%	0.012
Hispanic (yes)	na^b	na^b	na^b	0.31	10.5%	0.005
Obstetric risk (yes)	− 0.04	1.6%	0.5750	− 0.28	12.9%	0.002

na^a, not applicable; the data were prospectively denoised by removing datasets with motion; see the “Methods” section for details. na^b, not applicable; the ethnicity for FinnBrain participants was uniform—please see the “Methods” section and Table 1 for details
Abbreviations: BMI body mass index, MD mean diffusivity, QC quality control

ISSN: 1741-7015