Table 3 Treatment-associated protein signatures that were statistically significant between pre- and post-treatment samples
| Â | Post-chemotherapy relative expression | Post-endocrine therapy relative expression | ||||
|---|---|---|---|---|---|---|
Protein | Mean paired difference | Percent difference | Paired t test | Mean paired difference | Percent difference | Paired t test |
IL-17A | 0.3166 | 29% | 0.0132a | 0.0650 | 6% | 0.6717 |
IL6 | 0.5848 | 14% | 0.0038 | −0.1904 | −4% | 0.4658 |
CDCP1 | 0.4438 | 11% | 0.0040 | −0.3879 | −9% | 0.0085 |
CXCL10 | 0.8327 | 10% | 0.0077 | −0.5239 | −6% | 0.0579 |
CX3CL1 | 0.5470 | 9% | 0.0001 | −0.5142 | −8% | 0.0007 |
ADA | 0.3710 | 8% | 0.0003 | −0.2177 | −5% | 0.0470 |
CCL20 | 0.4305 | 8% | 0.0042 | −0.1810 | −3% | 0.4132 |
FGF-21 | 0.5143 | 8% | 0.0057 | −0.7357 | −10% | 0.0503 |
IL18 | 0.6073 | 7% | 0.0005 | −0.3188 | −4% | 0.0777 |
CCL3 | 0.3421 | 6% | 0.0073 | −0.2909 | −5% | 0.0168 |
IL8 | 0.3384 | 6% | 0.0101 | −0.3491 | −5% | 0.0720 |
MCP-1 | 0.5978 | 6% | 0.0000 | −0.2949 | −3% | 0.0538 |
Flt3L | 0.5379 | 6% | 0.0001 | 0.0005 | 0% | 0.9965 |
PD-L1 | 0.2038 | 5% | 0.0499 | −0.1732 | −4% | 0.0561 |
IL-10RB | 0.3209 | 4% | 0.0004 | −0.2137 | −3% | 0.0193 |
CCL23 | 0.4187 | 4% | 0.0005 | −0.4554 | −4% | 0.0038 |
uPA | 0.3538 | 3% | 0.0009 | −0.4534 | −4% | 0.0008 |
IL-12B | 0.1478 | 3% | 0.2428 | −0.3075 | −6% | 0.0375 |
CSF-1 | 0.2376 | 3% | 0.0014 | −0.0919 | −1% | 0.3834 |
CST5 | 0.1767 | 3% | 0.0437 | −0.0878 | −1% | 0.3355 |
MCP-3 | 0.0441 | 3% | 0.8297 | −0.3090 | −15% | 0.0330 |
CD40 | 0.2415 | 2% | 0.0168 | −0.2054 | −2% | 0.0166 |
MCP-4 | 0.0852 | 2% | 0.3817 | −0.3250 | −8% | 0.0286 |
VEGFA | 0.1733 | 2% | 0.0293 | −0.1070 | −1% | 0.3012 |
TNFRSF9 | 0.0322 | 0% | 0.7571 | −0.3080 | −5% | 0.0021 |
TRAIL | 0.0018 | 0% | 0.9841 | −0.2848 | −3% | 0.0273 |
TWEAK | −0.0133 | 0% | 0.8668 | −0.2412 | −2% | 0.0154 |
SCF | −0.0461 | 0% | 0.5764 | −0.3934 | −4% | 0.0029 |
CD5 | −0.0493 | −1% | 0.5766 | −0.2315 | −4% | 0.0193 |
TRANCE | −0.1874 | −4% | 0.0568 | −0.3970 | −9% | 0.0078 |
EN-RAGE | −0.9922 | −28% | 0.0051 | −0.3380 | −12% | 0.1530 |